Abstract :

The stability constants of binary complexes of metal ions   Cu²⁺, Ni²⁺, Co²⁺, Cr³⁺ and Zn²⁺ with Ritodrine Hydrochloride ligand were studied in aqueous media at 28⁰ C temperature. The Protonation constant and metal ligand stability constants were determined by Calvin Bjerrum titrations in combination with Microsoft excel software programme. 1 N NaNO₃ used to maintain ionic strength. Metal ligand ratio kept was 1: 1. The Protonation constant and metal ligand stability constants calculated by half integral and pointwise method found to be in agreement. Protonation constant obtained were 9.42 and 9.72. The decreasing order of stability of the complexes found to be Zn (II) < Cu(II) <  Co(II)  < Ni(II) < Cr(III) which is accordance to Irving-Williams order. Application of inexpensively available HNO_3, NaNO₃ and natural media are the salient features of the work. The results provide new insights into the complexation of ritodrine and its biological significance.

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Keywords :

Protonation constant, Ritodrine, Stability constant.

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