Title : Analysis of Risk Factors for Death in COVID-19 Patients at Bahteramas Regional General Hospital, Southeast Sulawesi Province

Vol 7 No 4 (2024): Volume 07 Issue 04 April 2024

Article Date Published : 30 April 2024 | Page No.: 2379-2386 | Google Scholar | Crossref doi for this article

Abstract :

Background: Coronavirus disease 2019, or COVID-19, is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 has been classified as a pandemic since 2020.

Purpose:  The purpose of this study was to determine the risk factors for death due to COVID-19 at the Bahteramas Public Hospital, Southeast Sulawesi Province.

Method: This research is a retrospective analytic study with a cross sectional approach. The number of samples is 85 samples. The sampling technique was purposive sampling. The data were processed using the Chi-Square test and Odds Ratio.

Results: This study shows that 47 people died at the Bahteramas Hospital in Southeast Sulawesi Province from March to November 2020, the variable age (p value = 0.001 and OR value 5.216), gender (p value = 0.078 and OR value = 2.180), hypertension variable (p value = 0.071 and OR value = 2.510), and diabetes mellitus variable (p value = 0.013 and OR value = 3.300).

Conclusion: Age, sex, hypertension, and diabetes mellitus are risk factors for death due to COVID-19 at Bahteramas Public Hospital, Southeast Sulawesi Province.

 

Keywords :

Age, COVID-19, diabetes mellitus, hypertension, Mortality, Sex

References :

  1. Sugihantono, A, Burhan E, Samuedro E, Aryati, Rinawati W, Sitompul PA, dkk. Pedoman Pencegahan da Pengendalian Coronavirus Disease (Covid-19). 5 ed. Jakarta: Kementerian Kesehatan RI; 2020.
  2. Pustake M, Tambolkar I, Giri P, Gandhi C. SARS, MERS and CoVID-19: An overview and comparison of clinical, laboratory and radiological features. J Fam Med Prim Care. Januari 2022;11(1):10.
  3. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, dkk. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. N Engl J Med. 26 Maret 2020;382(13):1199–207.
  4. Parry J. China coronavirus: cases surge as official admits human to human transmission. BMJ. 20 Januari 2020;m236.
  5. Virakul B, Chiangmai CN, Senasu K. Thailand and COVID-19 Pandemic: Lessons Learned, Challenges, and the Silver Linings. Dalam: Shultz I Clifford J, Rahtz DR, Sirgy MJ, editor. Community, Economy and COVID-19: Lessons from Multi-Country Analyses of a Global Pandemic [Internet]. Cham: Springer International Publishing; 2022 [dikutip 4 Maret 2024]. hlm. 505–30. (Community Quality-of-Life and Well-Being). Tersedia pada: https://doi.org/10.1007/978-3-030-98152-5_24
  6. Tosepu R, Effendy DS, Ahmad LOAI. The First Confirmed Cases Of Covid-19 In Indonesian Citizens. Public Health Indones. 20 Mei 2020;6(2):70–1.
  7. Handayani D, Hadi DR, Isbaniah F, Burhan E, Agustin H. Penyakit Virus Corona 2019. J Respirologi Indones. 2020;40(1):119.
  8. Burhan E, Susanto AD, Nasution SA, Ginanjar E, Pitoyo W, Susilo A, dkk. Pedoman Tatalaksana Covid-19. 4 ed. Jakarta: Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia; 2000.
  9. COVID-19 epidemiological update – 16 February 2024 [Internet]. 2024 [dikutip 4 Maret 2024]. Tersedia pada: https://www.who.int/publications/m/item/covid-19-epidemiological-update-16-february-2024
  10. Kemenkes RI. Perkembangan COVID-19 di Indoensia TAhun 2020-2024 [Internet]. 2024 [dikutip 4 Maret 2024]. Tersedia pada: https://infeksiemerging.kemkes.go.id/dashboard/covid-19
  11. Du P, Li D, Wang A, Shen S, Ma Z, Li X. A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients. Uhanova J, editor. Can J Infect Dis Med Microbiol. 10 April 2021;2021:1–12.
  12. Hashim MJ, Alsuwaidi AR, Khan G. Population Risk Factors for COVID-19 Mortality in 93 Countries: J Epidemiol Glob Health. 2020;10(3):204.
  13. Jackson CB, Farzan M, Chen B, Choe H. Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol. 2022;23(1):3–20.
  14. Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res. 16 Maret 2020;24:91–8.
  15. Harrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 Transmission and Pathogenesis. Trends Immunol. Desember 2020;41(12):1100–15.
  16. Chen Y. Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res Rev. 2021;
  17. Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, Evaluation, and Treatment of Coronavirus (COVID-19). Dalam: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [dikutip 6 Maret 2024]. Tersedia pada: http://www.ncbi.nlm.nih.gov/books/NBK554776/
  18. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, dkk. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 1 Juli 2020;180(7):934–43.
  19. Kang SJ, Jung SI. Age-Related Morbidity and Mortality among Patients with COVID-19. Infect Chemother. Juni 2020;52(2):154–64.
  20. Sasson I. Age and COVID-19 mortality: A comparison of Gompertz doubling time across countries and causes of death. Demogr Res. 2021;44:379–96.
  21. Fuentes E, Fuentes M, Alarcón M, Palomo I. Immune System Dysfunction in the Elderly. An Acad Bras Ciênc. Maret 2017;89(1):285–99.
  22. Valiathan R, Ashman M, Asthana D. Effects of Ageing on the Immune System: Infants to Elderly. Scand J Immunol. April 2016;83(4):255–66.
  23. Lee KA, Flores RR, Jang IH, Saathoff A, Robbins PD. Immune Senescence, Immunosenescence and Aging. Front Aging. 30 Mei 2022;3:900028.
  24. Wasityastuti W, Dhamarjati A, Siswanto. Imunosenesens dan Kerentanan Populasi Usia Lanjut Terhadap Coronavirus Disease 2019 (Covid-19). J Respirologi Indones. 2020;40(1).
  25. Hirokawa K, Utsuyama M, Kikuchi Y, Kitagawa M. Assessment of Age-related Decline of Immunological Function and Possible Methods for Immunological Restoration in Elderly. Dalam: Handbook of Immunosenescence. 2019.
  26. Franceschi C, Campisi J. Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases. J Gerontol Biol Sci Med Sci. 2014;69(S1).
  27. Ramírez-Soto MC, Ortega-Cáceres G, Arroyo-Hernández H. Sex differences in COVID-19 fatality rate and risk of death: An analysis in 73 countries, 2020–2021. Infez Med. 10 September 2021;29(3):402–7.
  28. Albitar O, Ballouze R, Ooi JP, Sheikh Ghadzi SM. Risk factors for mortality among COVID-19 patients. Diabetes Res Clin Pract. 1 Agustus 2020;166:108293.
  29. Capuano A, Rossi F, Paolisso G. Covid-19 Kills More Men Than Women: An Overview of Possible Reasons. Front Cardiovasc Med. 17 Juli 2020;7:131.
  30. Griffith DM, Sharma G, Holliday CS, Enyia OK, Valliere M, Semlow AR, dkk. Men and COVID-19: A Biopsychosocial Approach to Understanding Sex Differences in Mortality and Recommendations for Practice and Policy Interventions. Prev Chronic Dis. 16 Juli 2020;17:200247.
  31. Lipsky MS, Hung M. Men and COVID-19: A Pathophysiologic Review. Am J Mens Health. 1 September 2020;14(5):1557988320954021.
  32. Lisco G, Giagulli V, de pergola G, Tullio A, Guastamacchia E, Triggiani V. Covid-19 in Man: A Very Dangerous Affair. Endocr Metab Immune Disord – Drug TargetsFormerly Curr Drug Targets – Immune Endocr Metab Disord. 1 September 2021;21.
  33. Pranata R, Lim MA, Huang I, Raharjo SB, Lukito AA. Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: A systematic review, meta-analysis and meta-regression. J Renin-Angiotensin-Aldosterone Syst JRAAS. 14 Mei 2020;21(2):1470320320926899.
  34. Du Y, Zhou N, Zha W, Lv Y. Hypertension is a clinically important risk factor for critical illness and mortality in COVID-19: A meta-analysis. Nutr Metab Cardiovasc Dis. Maret 2021;31(3):745–55.
  35. De Almeida-Pititto B, Dualib PM, Zajdenverg L, Dantas JR, De Souza FD, Rodacki M, dkk. Severity and mortality of COVID 19 in patients with diabetes, hypertension and cardiovascular disease: a meta-analysis. Diabetol Metab Syndr. Desember 2020;12(1):75.
  36. Gao C, Cai Y, Zhang K, Zhou L, Zhang Y, Zhang X, dkk. Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study. Eur Heart J. 7 Juni 2020;41(22):2058–66.
  37. Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr Clin Res Rev. 1 Juli 2020;14(4):395–403.
  38. Barron E, Bakhai C, Kar P, Weaver A, Bradley D, Ismail H, dkk. Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol. Oktober 2020;8(10):813–22.
  39. Varikasuvu SR, Dutt N, Thangappazham B, Varshney S. Diabetes and COVID-19: A pooled analysis related to disease severity and mortality. Prim Care Diabetes. 1 Februari 2021;15(1):24–7.
  40. Wu Z hong, Tang Y, Cheng Q. Diabetes increases the mortality of patients with COVID-19: a meta-analysis. Acta Diabetol. 1 Februari 2021;58(2):139–44.
  41. Hill MA, Mantzoros C, Sowers JR. Commentary: COVID-19 in patients with diabetes. Metabolism. Juni 2020;107:154217.

 

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Analysis of Risk Factors for Death in COVID-19 Patients at Bahteramas Regional General Hospital, Southeast Sulawesi Province. Hadiyoga Pratama Putra, Arimaswati, Alfiyyah Hastari Syaf, Iwan Derma Karya , 7(4), 2379-2386. Retrieved from https://ijcsrr.org/single-view/?id=15977&pid=15671

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