Abstract :

Buccal films has distinct advantages over conventional dosage forms. Drugs can be delivered through  buccal route, by avoiding first pass metabolism to produce local and systemic action. Rapid absorption of the drug is achieved because buccal mucosa is highly permeable with rich blood supply. Only few dosage forms are designed to deliver the drug through this route. Leaf extract of Mimosa pudica has number of pharmacological actions. Buccal film  of leaf extract of mimosa pudica is prepared by solvent casting method and evaluated  for its characteristics. Six formulations were prepared, out of which F3 formulation was found promising formulation, releases 96.13% of drug in 10 minutes.

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Keywords :

Buccal mucosa, folding endurance, mimosa pudica, permeable.

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References :

1. Jacob, A.B. Nair, S.H.S. Boddu, B. Gorain, N. Sreeharsha, J. Shah An updated overview of the emerging role of patch and film-based buccal delivery systems Pharmaceutics., 13 (8) (2021 Aug 5), p. 1206
2. Speer, M. Preis, J. Breitkreutz Dissolution testing of oral film preparations: experimental comparison of compendial and non-compendial methods Int. J. Pharm., 561 (2019 Apr), pp. 124-134
3. Hoogstraate J, Benes L, Burgaud S. Oral transmucosal drug delivery systems. In: Hillery AM, Lloyd AW, Swarbrick J, editors. Drug delivery and targeting.London: Taylor and Francis; 2001. pp. 186–200.
4. Alagusundaram M, Chengaiah B, Ramkanth S, Parameswari SA, Chetty CM, Dhachinamoorthi D. Formulation and evaluation of mucoadhesive buccal films of ranitidine. International journal of pharmtech research. 2009 Jul;1(3):557-63.
5. Ahuchaogu A., Chukwu J., Obike A., Ugonna Oha T., Bull J., Echeme O. Quantitative Determination of Secondary Metabolites and Antibacterial Activity of Mimosa Pudica.  J. Med. Plants Nat. Prod. 2017;3:2454–7999.
6. Racadio S.P. The Medicinal Prospects of Makahiya (Mimosa Pudica Linn) Plant.  Life Sci. 2016;6:7–12.
7. .Joseph B, George J, Mohan J. Pharmacology and traditional uses of Mimosa pudica. International journal of pharmaceutical sciences and drug research. 2013;5(2):41-4.
8. James JP, Priya S, Jyothi D. Nanoparticulate Hydrogel Incorporated with Mimosa pudica Extract: Formulation and Characterization. In10th Int. Conf. Biol. Biomed. Med. Pharm. Sci.(Cellular Mol. Approach) 2017 (pp. 104-109).
9. Manikiran SS, SANTHI PRIYA NA, AUBINE MOLLY B, LAKSHMI PRASANTHI NO. Fabrication and characterization of fast dissolving films of eclipta prostrate leaves extract to treat mouth ulcers. International Journal of Applied Pharmaceutics. 2021;13(5):263-71.
10. Waghmare P, Mithun M. FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM CONTAINING EXTRACTS OF OCIMUM SANCTUM AND GLYCYRRHIZA GLABRA TO TREAT MOUTH ULCER.
11. Bhutkar KG. Formulation and evaluation of mucoadhesive herbal buccal patch of Psidium Guava L. Journal of Current Pharma Research. 2014 Oct 1;5(1):1372.
12. Rajani BK, Kulkarn SV. Design and characterization of fast dissolving buccal film of imipramine HCL. World Journal of Advanced Research and Reviews. 2022;16(2):258-70.
13. Rao NG, Munde MR. Formulation and in-vitro evaluation of mucoadhesive buccal films of zolmitriptan. J Pharm Res. 2011 Aug;4:2682-5.