Finding the Therapeutic Role of miRNAs in Hepatocellular Carcinoma (HCC)

Hepatocellular carcinoma (HCC) has become the second most common cause of cancer-related death worldwide, with approximately 782,500 new cases and 745,500 deaths occurring in the global during 2012. The main objective of the study is to find the therapeutic role of miRNAs in Hepatocellular Carcinoma (HCC). This study was conducted using a systematic search on Google scholar, Pubmed and Web of science published until 20^th June 2020. The cited references of retrieved articles and previous reviews were also manually checked to identify any additional eligible studies. MiRNAs perform their tumor suppressor functions through downregulating oncogene expression. Increasing evidence suggests that miRNAs are essential for the regulation of liver development, regeneration, and metabolic functions. It is concluded that deregulation of miRNAs significantly contributes to the development of HCC. miRNAs mainly functions to down regulate the expression of targeted genes. However, they may have other yet unknown functions including the activation of gene transcription.