This paper reviews water quality parameters and their health effects on humans with the objective of enlightening the public on drinking water guidelines, the focal point and protection measures. It is also intended to help evade the health catastrophe that manifests as a result of ingesting water containing substances in excess concentration of recommended limits. Sources of water are reviewed, including rain water, surface water and groundwater. The presence and level of the biological, physical and chemical constituents referred to as water parameters which determine its suitability for drinking were also reviewed. Biological parameters are microorganisms, while physico-chemical parameters include temperature, color, dissolved solids, cations, etc. Drinking water quality standards as well as the health impacts of water quality parameters were discussed. Some of the health impacts include water borne diseases, organ failures, cancer, neurological damage, etc. The paper concludes that microorganisms and chemical constituents in drinking water sources and supply can directly or indirectly impair the use of the water for human consumption. Recommendations were made including the disinfection of drinking water sources to prevent growth of disease causing organisms, hand washing to prevent infections including Covid 19 virus and laboratory assessment of water quality parameters to ascertain their conformity with drinking water standards.