Recent Advances in the Treatment of Irritable Bowel Syndrome: Addressing Diarrhea, Constipation, and Abdominal Pain

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Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by abdominal pain, bloating, and changes in bowel habits. This paper aim was to provide an overview of recent advancements in the treatment of IBS, focusing on the management of its main symptoms: diarrhea, constipation, and abdominal pain.

For individuals with IBS-D, various therapeutic options are available, including rifaximin, peripheral opioid agonists, mixed opioid agonists/antagonists, bile acid sequestrants, and serotonin 5-HT3 receptor antagonists. Rifaximin, a nonabsorbable antibiotic, has demonstrated significant effectiveness in reducing IBS symptoms, such as bloating and loose stools, with good tolerability and safety. Also the repeated use of rifaximin for managing recurrent IBS symptoms. In IBS-C patients, bulking agents, osmotic laxatives, and prokinetic agents like lubiprostone have shown efficacy in improving constipation and overall symptoms. Linaclotide, a drug that increases intestinal chloride secretion, has demonstrated significant improvement in bowel movements and abdominal pain in IBS-C patients. However, it may cause diarrhea in some individuals. IBS-M, characterized by alternating constipation and diarrhea, poses a challenge in terms of specific drug treatments. A comprehensive assessment of potential underlying causes and careful history taking is crucial for effective management. Abdominal pain is a common symptom in IBS, regardless of subtype. Antispasmodic drugs, peppermint oil, and trimebutine have shown effectiveness in reducing pain and improving symptoms. Antidepressants, such as tricyclic antidepressants and selective serotonin reuptake inhibitors, may offer relief by modulating pain pathways and influencing gastrointestinal motility. Benzodiazepines, particularly dextofisopam, have shown potential in improving stool consistency but require further evaluation.

In conclusion, recent advancements in the treatment of IBS have provided a range of therapeutic options targeting its main symptoms. However, further research is needed to develop tailored treatments for specific IBS subtypes and to explore the efficacy of potential alternatives, including benzodiazepines. Improved management of IBS symptoms can significantly enhance the quality of life for affected individuals.

Evaluation of Lateral Load Resisting Systems in High-Rise Buildings

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The rapid urbanization and the scarcity of residential space in metropolitan areas necessitate the construction of tall structures to meet the growing accommodation demands. This research paper focuses mainly on the structural act of high-rise structures under lateral loads, especially earthquake forces. Three lateral load resisting systems, namely outrigger system, shear wall at core and shear wall at corner are compared and analysed. The study reviews relevant literature, discussing parameters affecting the fundamental time period of structural models and the effectiveness of distributed belt wall systems. The research methodology involves the analysis of a 40-storey regular office building using three different lateral load resisting systems. The results obtained through response spectrum analysis, shows that the outrigger system exhibits efficient structural capability in tall buildings. The maximum lateral displacement is significantly reduced in the outrigger system compared to core shear-wall and corner-shear wall. The study concludes that enhancing lateral load resistance and providing a transition path to perimeter columns subjected to lateral load, as seen in the outrigger-system, proves effective in mitigating the impact of earthquake loads on high-rise buildings.

 

Evaluation of Travel Time and Cost Burden for Working: A Case Study of Jalalabad City, Nangarhar, Afghanistan

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Evaluating travel time and cost burden for working in Jalalabad city is one of the key challenges for employees to use their modes of transportation for working place and as well as to examine the travel time difficulties encountered by those traveling to work in Jalalabad city. The everyday commute in urban areas has a substantial influence on the overall quality of life as a whole with longer travel times and congestion putting a strain on commuters’ fulfilment, efficiency, and happiness. Understanding and properly measuring these are critical for politicians and urban planners when developing successful transportation systems and policies. To meet the goals, multiple methods for estimating trip times were used, including survey-based techniques. To gather data on travel behaviors and trip times, declared preference questionnaires and indicated preference surveys were undertaken. The research investigated the average commute time and expense for several professional subjects and places, providing light on the differences in challenges faced by persons in various sectors. In addition, the overall average trip time and cost for various means of transportation were investigated to determine the effectiveness and affordability of every choice. The study’s findings add to the current research by focusing on Jalalabad city, Nangarhar and evaluating commute time burdens for work in the city. This small study wants to improve Jalalabad’s transit system and employees’ well-being by identifying suitable modes of transportation for commuters and important variables impacting these burdens and suggesting feasible solutions. The findings give useful insights for politicians and urban planners in developing specific programs to reduce commuter travel time barriers.

Passive Filter to Reduce Harmonics in Architecture Building of Samarinda State Polytechnic

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The use of non-linear loads can cause harmonics in both current and voltage in the electrical system. Non-linear loads are generated from the use of electrical equipment such as computers, air conditioners, semiconductors, and other switching electrical equipment. Harmonics that exceed the standard will have an impact on the quality of the power supplied. The use of Single-Tuned passive filters aims to reduce harmonics both current and voltage in the electrical system of the Samarinda State Polytechnic Architecture Building. This research explains how to calculate the Single-Tuned filter and how to input the calculation results into the ETAP software used to simulate the effect of using a Single Tuned filter to reduce harmonics. In this study, it is known that the use of a 5th-order Single-Tuned filter using ETAP software can reduce the THDi value of phase R from 80.43% to 6.27% where based on IEEE 519-2014 standard THDi value for SCRatio 100-1000A is 15%. The IEEE 519-2014 standard for THDi of 15% is obtained by calculating ISC and IL first.

Reform of College English Teaching Content in Engineering Colleges against the Background of New Engineering Education

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In recent years, increasing attention has been paid to the development of new engineering education. College English, a compulsory course aimed at non-English majors in China’s universities, bears great responsibilities in training high-quality innovative engineering talent with an international perspective. After an examination of the current College English teaching content and an analysis of college students’ needs for English learning, the paper proposes three ways to reform the teaching content of College English in light of nurturing new engineering talent: integrating language and cultural knowledge with subject-specific knowledge, enhancing students’ ability of applying English in their professional domains, and emphasizing both humanistic education and professional competence in College English teaching.

Relevance of IPR in Small Businesses

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Small businesses in India have always been one of the major occupations in rural as well as urban terrain and they are major source of income for the middle class group. As urbanization has increased the demand for the small services like grocery shops, bakeries, vegetable shops, laundry shops, juice centers, sweet shops, small hotels etc. Majorly the urban population is a mix of all the classes of people but a considerable portion is occupied by the middle and low income group, which has resulted in requirement of small services, and retail shops. As of a result of which the small businesses mushroom in the different localities, in different sizes so that they can cater to all the segments of consumers. Small business organizations contribute to the economy significantly by distributing the finished goods to the ultimate consumers, and they also create jobs in smaller units. The large business organizations contribute to economy by creating jobs in a bulk, economies of scale. The large scale organizations have the accessibility to hire legal professionals like legal advisers and naturally they give the suggestions on legal aspects for a smooth conduct of the business. In this context large or medium sized organizations have proximity to legal protection for their inventions, design, copyrights, trademarks etc, and they consciously protect their rights by patents or trademark and so on. In this article we have made an attempt to understand the extent of application of IPR in small and micro businesses.

Determining of Well Drilling Sequence for Investment Analysis using Monte Carlo Simulation in Upstream Oil and Gas Company in East Kalimantan, Indonesia

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Electrical construction company that experienced in making Well Head Control Panels (WHCP) has difficulties to decide acceptance of investment in WHCP contracts raised with their client in upstream oil and gas company. The difficulty mostly due to uncertainty of client well drilling sequence. The electrical construction company need to financial investment analysis includes material purchasing, shipping, fabrication and delivery of WHCPs need to be done to make sure they make a profit. It is crucial for electrical construction company used correct forecasting method to determine schedule of client’s request. Monte carlo forecasting method is used to predict the well drilling sequence. The well drilling sequence data for 12 months is used to determine 24 months well drilling sequence operation with result 179 wells with normal distribution and 167 wells with triangular distribution.

Knowledge, Attitude, and Practices (KAP) in Complementary and Alternative Medicine (CAM) Among Selected Asian Countries: A Literature Review

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: This literature review examines the landscape of Complementary and Alternative Medicine (CAM) in selected Asian countries, focusing on knowledge, attitudes, and practices (KAP) among healthcare professionals and the general population. Drawing insights from studies conducted in Bangladesh, Iran, Malaysia, Thailand, Nepal, Oman, Pakistan, Saudi Arabia, and the Philippines, the review highlights the increasing interest in CAM as a holistic approach to health and well-being. While positive attitudes towards CAM are prevalent, challenges such as knowledge gaps, concerns about evidence, and limited integration into clinical care persist. The review underscores the importance of education, research, and policy interventions to promote the safe and effective use of CAM, enhance healthcare quality, and meet the diverse healthcare needs of populations in the region. Recommendations include investing in educational programs, supporting research initiatives, and raising public awareness to advance healthcare systems’ capacity in integrating CAM practices effectively.

Brazil’s Economic Potential with Carbon Credits: A Study of the “Mata Do Buraquinho” – Brazil

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Introduction: Public (state) concern about the climate has, in turn, catalyzed the creation between global governments and transnational companies, and these models are subject to risk-consequence type measures, the conduct of which is now known as the voluntary carbon credit market. The article in question deals with one of the most talked-about economic instruments for combating global warming in international politics, the carbon credit market.

Objective: The article in question proposes a reflection on this subject, which has been so much talked about in recent years, focusing on its economic perspective and using a case study methodology to support its results.

Theoretical framework: The mitigation of greenhouse gas (GHG) emissions is a necessary condition to lead to a low-carbon economy, and the best way to achieve this is through the application of economic instruments. Such as putting a price on carbon, making this transition quicker and less costly from a social point of view. In this way, with a higher relative price for pollution, private agents will choose between paying for or reducing pollution, comparing the marginal cost of control with the price of carbon.

Methodology: Initially, a bibliographical review was made of the economic theoretical framework that underpins one of the instruments considered most efficient in combating climate change, the carbon credit market. In another part of this work, a practical application of this mechanism was carried out, using an evaluation methodology for an application of this instrument in the municipality of João Pessoa -PB, which stands out for being one of the most wooded cities in Brazil and for having some conservation units in its territory, such as the one used in the work, the Mata do Buraquinho Wildlife Reserve.

Results: The sale of the ecosystem services that the forest offers, in this case its capacity to absorb CO2, could improve the conditions for maintaining the area and perhaps attract more people to visit it. Thus, the value found for “Mata do Buraquinho” was R$61,968.26.

A Study of The Consumer Profile of Fresh Chicken B2B in Jakarta Province (Case study of Processed Noodle Restaurants)

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: The study aims to comprehensively investigate the consumer profile of fresh chicken in Jakarta, with a special focus on processed noodle restaurants, especially ramen and bakmi restaurants as the main customers in business-to-business (B2B) transactions. This research is expected to serve as a basis for further analysis on how supply companies, especially the fresh chicken industry, can explore consumer preferences, purchasing behavior, motivational factors, and challenges faced in obtaining and using fresh chicken, especially in the DKI Jakarta province. The research was conducted using a survey method with a sampling technique using purposive purposive sampling with predetermined criteria of noodle processed restaurant managers. Farmers who were used as respondents amounted to 100 respondents. The analysis method used is descriptive with mode measurement or the most frequently occurring value. The results showed that the managers of processed noodle restaurants in Jakarta province are mostly in the age group of 26-35 years with 61% (61 people), 64% (64 people) have a Bachelor’s degree. Most respondents have more than 3 years of work experience, namely 52% (52 people). The majority of the location distribution of processed noodle restaurants in DKI Jakarta province is in the city of South Jakarta (34%) and the majority of restaurants have an average number of workers between 10-20 people per outlet (83%), while 79% of restaurants have chicken meat needs between 10-20 kg.