Analysis of The Influence of Brand Awareness, Brand Image and Price on Purchasing Decisions for Samase Products in Jakarta

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The demand for Muslim clothing is increasing rapidly. This is happening because of the increasing population of Muslims every year, so fashion companies must be able to meet consumer needs. Samase, as a fashion company, has a strong commitment to fulfilling consumer rights, especially in meeting the demands of Muslim consumers. Evidence of this commitment can be seen from the number of agents/distributors spread across the DKI Jakarta area. This study uses a quantitative approach with the aim of proving and analyzing the effect of brand awareness, brand image, and price on purchasing decisions for Samase products in Jakarta. The sampling technique used was purposive sampling, with a total sample of 100 respondents. The collected data were analyzed using descriptive analysis techniques and inferential analysis using the SmartPLS application (V.3.29). The results of this study indicate that: (1) Brand awareness has a positive and significant impact on purchasing decisions, with a path effect of 0.515. (2) Brand image also has a positive and significant influence on purchasing decisions, with a path effect of 0.515. 0.286. (3) In addition, price also influences purchasing decisions positively and significantly, with a path effect of 0.141 Overall, brand awareness, brand image, and price together contributed 0.733 (73.3%) to purchasing decisions, while the remaining 0.267 (26.7%) was influenced by other factors outside this research model.

Investigation of Momordica charantia phytochemicals against PIM1 Kinase: A Computational Approach

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Prostate cancer is a significant contributor to male cancer-related mortality. PIM1 kinase has implications in the development and progression of various cancers, particularly prostate cancer. PIM1, a serine/threonine protein kinase plays a crucial role in cellular processes including survival, growth and differentiation. In prostate cancer increased PIM1 expression is associated with a more aggressive phenotype and poorer patient outcomes. It has emerged as a promising therapeutic target for prostate cancer treatment. The development of PIM1 kinase inhibitors has greatly enhanced and progressed significantly. Different stages of clinical trials demonstrating their potential as therapeutic agents. Momordica charantia, or bitter melon has a long history in traditional medicine for various health conditions, it is very rich in secondary metabolites like triterpenoids, glycosides, alkaloids, flavonoids and phenolic acids. Bitter melon is considered to have medicinal properties including potential anticancer phytochemicals. This study employs virtual screening, molecular dynamic simulation and ADME/T analysis to explore bitter melon’s phytochemicals and their interaction with PIM1 kinase. The goal is to understand the molecular details and pharmacokinetics of bitter melon compounds evaluating their potential as therapeutic agents against prostate cancer. In our present study, it was found that out of all investigated phytochemicals catechin and gallic acid shows satisfactory result depending upon various parameters taken into consideration for conducting the study.