Effect of Substituents on the Biological Activity of Isatin Hybrids – A SAR Study

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Isatin (2,3-dioxindole) is a benzopyrrole derivative that belongs to a large class of heterocyclic chemicals. Isatin derivatives are essential synthetic substrates that can be utilized as starting materials to build a wide range of heterocycles with diverse applications in pharmaceutical sciences. Isatin derivatives therefore have recently gained a lot of attention. This review emphasizes on the Schiff base derivatives from isatin, isatin quinoline/flouroquinone, isatin -thiazole, isatin–azole hybrids, all possessing potential biological activity. The structure–activity relationships of these potential leads are also discussed.

Impact Prenatal Yoga Training on the Length of Labor in Kendari City

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Background: Prenatal yoga is a slow movement exercise combined with breathing exercises to maintain the posture of the mother-to-be, calm the soul, and prepare for birth by reducing pain, increasing physical and psychological comfort.

Purpose: To determine the effect of the combination of prenatal yoga on the length of labor at the Nambo Public Health Center.

Method: quasi-experimental with Non-Equivalent Group Design. The sample is pregnant women in the working area of the NamboPublic Health Center, totaling 60 people consisting of 30 treatment groups and 30 control groups. Sampling with purposive sampling technique. Data analysis using t-test.

Conclusion: There is an effect of prenatal yoga practice on the duration of the second stage of labor in the working area of the Nambo Health Center, Kendari City.

Internal and External Determinants of Firm Value: A Study on the Manufacturing Companies in Indonesia

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This study describes the influence of internal and external factors of the company on firm value which is a verification study using an explanatory survey method. The data used is secondary data available on the official website of the Indonesia Stock Exchange. While the type of data used is quantitative data. The sampling method is to use a purposive sampling method, so that 7 companies can be sampled in this study.

The results of this study indicate that all variables indicate that the company’s internal and external factors have an influence on the Firm Value of the food and beverage sub-sector listed on the Indonesia Stock Exchange in 2014-2020. Suggestions for companies, namely companies need to improve company performance in order to increase Firm Value, especially the use of costs and working capital management which can increase positive perceptions from investors so that they are reflected in Firm Value.

Evaluation of Physical Fitness and Motor Ability of Brazzaville’s U19 Football Players According to the Playing Positions

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This study aims to evaluate the physical fitness and motor ability of Brazzaville’s U19 footballers according to playing position. Method: A cross- sectional study was conducted with a total of 33 U19 football players aged 18.75 ± 0.95 years. Data collection consisted of anthropometric measurements, physical fitness (YYIR1 distance and VO2max) and motor ability (agility, explosive power and upper limbs strength) and the playing positions. Agility, explosive power and upper limbs strength (Barrow moter ability test) whereas YYIR1 distance and VO2max (YO-YO intermittent recovery level 1) were measured on three separate days. The data were analyzed using SPSS software 25.0. Results: Explosive powers as well as upper limb strength were significantly higher in goalkeepers than in midfielders, attackers and defenders (p < 0.001; p < 0.001). The distance covered by midfielders and VO2max were significantly higher than that of defenders, attackers and goalkeepers (p < 0.001; p <0.001). Conclusion: Physical fitness was high among midfielders while motor ability was high among goalkeepers. The different playing positions on the field are characterized by specific activities and physical requirements.

Prevalence and Pattern of Sexual Assaults among the Mentally Ill attending the University of Port Harcourt Teaching Hospital

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Background: Sexual assault among the mentally ill has become a common trend of public health concern occurring in various forms and perpetrated by different classes of individuals. It has become a more accurate predictor of suicidal ideation and attempt than any other form of abuse.

Aim: This study determined the prevalence and pattern of sexual assaults among the mentally ill attending the University of Port Harcourt Teaching Hospital.

Materials and Methods: This was a descriptive cross-sectional study conducted among attendees of Neuropsychiatric Outpatient Clinic of the University of Port Harcourt Teaching Hospital (UPTH). A structured questionnaire covering socio-demographic characteristics and other factors were self-administered to 75 patients diagnosed with various psychiatric disorders by consultant Psychiatrists at the out-patient clinic via a systematic random sampling method. Ethical approval was obtained from the ethical committee of the University of Port Harcourt Teaching Hospital. Descriptive statistics was used to analyze the data.

Results: Majority of the mentally ill patients were male (81%), had tertiary education (58.7%), and between the ages of 21 and 30 (44%). The most common mental illness experienced by victims of sexual assault include depression 21(28.0%), the least being sleep and personality disorders 1(1.3%). 16% reported that they had experienced sexual assault, and majority (38.7%) reported that the assault occurred when they were between the ages of 10 and 18. Majority of perpetrators of sexual assault were siblings 5(6.7%), followed by mother 3(4.0%). Some percentage was strangers (1.3%), with the rest being either a visitor to the house (1.3%), or neighbor (1.3%). Only (2.7%) of those who experienced sexual assault reported the assault, (9.3%) did not report it, while 66 (88%) had no response.

Conclusion: Sexual assault among the mentally ill is on the rise and manifests in several forms. Measures should be taken by all stakeholders including the government to curb this ugly trend.

Measurement of Service Quality Perception, Customer Satisfaction, and Customer Loyalty in PT Medika Antapani

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Indonesia had 11,347 clinics in 2020, 10,238 Pratama, and 1,109 Utama. West Java Province had the most clinics in 2021, with 6,572 Pratama and 1,042 Utama. Private Bandung public health provider PT. Medika Antapani 2020–2021 customer visits decreased. Pratama clinics in Kiaracondong have almost doubled to 15 clinics, giving cash clients many options. To compete, health services must constantly improve service quality to satisfy customers and build loyalty.

This research helps PT. Medika Antapani meet customer service needs. The author uses a descriptive and causal research design. The author distributes Likert scale questionnaires to 200 respondents who meet the criteria. According to a descriptive analysis of 200 respondents, most are male, 60-74 years old, live in Cisaranten Endah, are employees, and use general practitioner services. The total average for causal analysis was 3,088, 3,127, and 2.93 for service quality, satisfaction, and loyalty. Satisfaction and service quality affect loyalty by 84.1%.

Service quality improvements are needed in PT Medika Antapani for addressing six areas, including low scores on the latest equipment, recruiting Ob-Gyn doctors, and providing reminder messages. For future recommendations, PT Medika Antapani must evaluate its services to maintain quality and develop in areas service users need.

Student-Centred Studio Environments: A Deep Dive into Architecture Students’ Needs

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Architectural education has long placed a strong emphasis on the studio, which serves as a crucial place for teaching and learning. The architecture studio is a dynamic and lively place where students can engage in design discussions, exchange ideas, and receive feedback from instructors and peers. Despite recognising the vital role architecture studios play in shaping the learning experience of architecture students, limited research has explored which specific attributes of the studio environment are most important to students. This research aims to address this gap by determining the priorities of architecture students regarding key studio attributes. The research employs a quantitative approach using the Best-Worst Scaling (BWS) model and a questionnaire survey. A pilot study was conducted with undergraduate architecture students. The results reveal the ranking and relative importance of key studio attributes, organised into five categories: Physiological Facilities, Information and Communications Technology, Indoor Environment Quality, Territoriality, Furniture, and Reference. This research provides a valuable reference for designing student-centred studio environments and demonstrates the viability of using the BWS method to determine students’ priorities for studio attributes.

The Effect of Salinity on the Initial Growth of Soy Varieties

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The article presents the data obtained on the study of the characteristics of soil salinity on the initial growth of different soybean varieties in the conditions of the Bukhara region. During the experiments, it was found that during the first 21 days of the plant, stem and root growth and dry mass accumulation. Based on the above results, it was noted that the above indicators vary in different degrees depending on the soil salinity and the biological and various characteristics of the varieties.

Proposed Digital Marketing Strategy Using Existing Customer Journey Analysis Case Study: PT SS

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PT SS is an Indonesian electricity provider that has been in operation for over 25 years. PT SS has a primary client in the utilities industry. In 2018, the government implemented a regulation that decreased the company’s revenue. In order to boost revenue, market penetration must be increased. With digital marketing, the objective is to expand the market to non-utility industries.Currently, the internet serves as a medium for discovering information anywhere and for connecting individuals with one another. In addition to this, it can also be utilized for media marketing. Digital marketing is a sort of business in which a person or company engages in internet-based marketing. Both B2C and B2B companies can utilize digital marketing media to promote their products.This paper provides an overview of PT SS’ issues, specifically unsuccessful digital marketing. The analysis is conducted utilizing internal analysis, namely Marketing Mix and STP, external analysis, including PESTLE, Five Porter Analysis, and competitor analysis, followed by SWOT analysis. Then, customer journey analysis is utilized to determine the consumer’s journey when dealing with PT SS via the Internet. To create a digital marketing plan, the writers use the RACE framework to develop marketing strategies for new and existing PT SS customers. Utilizing this approach, the right use of social media and digital marketing methods to handle PT SS’s issues is determined.

Proposed Marketing Strategy for Honda WR-V to Improve Brand Awareness and Customers’ Purchase Intention in Central Java and Yogyakarta

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Honda WR-V was officially launched in Indonesia in November 2022. This Small SUV car is now being promoted around Indonesia, including Central Java and Yogyakarta area. As a new released car, this car should be promoted routinely by the company who represents Honda for Central Java and Yogyakarta. However, that did not seem to be the case as the company was focused on other unit marketing campaign and only relied on uploading simple social media content as well as displaying the car in dealers’ exhibitions. The company’s marketing team needed to create a well-planned marketing strategy to further improve customers’ brand awareness towards this car and to convince them that this car is superior compared to its competitors in the same segment. Thus, it could eventually lead to increase customers’ purchase intention. This study is conducted to understand customers’ brand awareness and perceptions towards Honda WR-V in Central Java and Yogyakarta, and to understand customers’ complex buying behaviour to purchase a car. Focus group discussions were conducted with 20 respondents to gain insights from their point of views. The proposed strategy was developed from internal and external analysis which was summarized into SWOT analysis and TOWS matrix. These findings then were developed into an integrated marketing communication plan as the final proposed marketing strategy for the company to further improve brand awareness and customers’ purchase intention towards Honda WR-V.