Nootropic Activity of Ethanolic Extract of Zingiber officinale and Centella asiatica on Stress Induced Rats

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Nootropics, natural or synthetic substances that boost brain function and cognitive abilities, were investigated in this study. Specifically, the effects of Zingiber officinale and Centella asiatica extracts were compared to the standard nootropic piracetam. Both plant extracts demonstrated nootropic activity and contained phytochemicals like flavonoids, tannins, and saponins that protect the brain from oxidative damage. Sterols such as stigmasterol inhibiting acetyl CoA esterase activity were also present. Tests were conducted on rats given the extracts or piracetam daily for 7 to 21 days. High and low doses were used. Nootropic effects were measured using elevated plus maze and Morris water maze tests compared to controls. The results were promising: At higher doses, the extracts significantly reduced latency time to 21 ± 0.33 seconds compared to 33.33 ± 0.12 seconds for piracetam and 54 ± 0.08 seconds for controls. This suggests the plant extracts have considerable nootropic potential when administered at higher doses.

Development and Characterization of Solid Dispersion of Rasagilline Mesylate for Improvement of Dissolution Rate Using Hydrophilic Carriers

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The aim of present study was to improve the solubility of Rasagilline mesylate, an Atypical Antipsychotic agent which is BCS Class III drug and thus has very low solubility and hence very poor bioavailability owing to less absorption. Moreover Rasagilline mesylate has a bitter taste. Thus in the present study an attempt was made to taste mask the bitter taste of drug and improve oral bioavailability of drug by formulating the drug into solid dispersion and then formulate the solid dispersions into Fast Dissolving Tablets. Solid Dispersions of Rasagilline mesylate were formulated using various polymers like Plasdone K30, plasdone K90, Eudragit RS100, Eudragit RL 100, Poloxamer 188 and Soluplus in different ratios viz., 1:1 and 1:2 by solvent evaporation method and evaluated for various physicochemical parameters. On the basis of evaluation parameters Solid Dispersion containing Drug : Soluplus :: 1 : 2 was optimized batch having Solubility 1.91 mg/ml, Drug content 102.75 % and % CDR of 98.43 % at 35 mins. For formulating Fast Dissolving Tablets, 32 factorial designs was applied where the batch SD12 and Concentration of Chitosan were taken as dependent variable X1 and X2, respectively and wetting time (sec.) and in vitro disintegration time (sec.) and % CDR were taken as an independent variables. All the formulation prepared by applying experimental design showed more than 93 % drug release in 15 mins. Batch F9 was selected as an optimized batch from the data of overlay plot, drug release kinetics and checkpoint batch. A stability study for optimized formulation was carried out as per ICH guidelines, showed no significant changes in the evaluation parameters. Thus from the study it can be concluded that Fast Dissolving Tablets of Rasagilline mesylate formulated from solid dispersions can provide rapid drug release within a short period of time.

Strategic Planning for Drone Company in Indonesia (Case: PT Terra Drone Indonesia)

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Terra Drone Indonesia has the vision to be the No. 1 drone service company in Southeast Asia and contribute to the nation’s sustainable growth. The drone business condition in Indonesia is getting tight with competition and regulation. A new strategic plan should be proposed to answer the vision of Terra Drone Indonesia. Understand drone business opportunities to explore more for Indonesia’s drone industry business issues. The internal environment (SWOT Analysis) and the external environment (5 forces, PESTEL) will be a study for the proposed business strategy. The feasibility study and new business strategy comparison analysis turn into a strategy implementation for Terra Drone Indonesia. 2 new drone businesses might be applicable in Indonesia. Those are Drone spraying and Drone light show businesses. These 2 applications also the drone services that can comply with the waiver drone operation in Indonesia. Drone Spraying complies with a specific airspace operation and drone light show is more than one drone operation. New business strategic planning should be arranged by TDID as a more narrow Strategy. Based on the analysis, drone light show business fit more. Low competition and higher financial projections are the key points compared to the drone spraying business. The implementation plan should be monitored well to make sure the new strategy solves the problem.

Job Insecurity and Psychological Wellbeing: Is it Necessary to Foster Employee Performance

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Trends 2022 report warns of a slow and uncertain recovery, as the pandemic continues to have a significant impact on global labor markets. Layoffs treat experienced by the blue-collar employee in hospitality industries in Indonesia. This study aims to examine the relationship between job insecurity and psychological wellbeing on employee performance. The sample of the study was 289 blue-collar employees in Surabaya Indonesia, recruited through simple random sampling, from October through the end of November 2022. The result show that job insecurity was positive and significant related to employee performance (β =0 .213, p = 0.033). Job insecurity was indicated negative and significant to psychological wellbeing (β = – 0.421, p=0,001). Psychological wellbeing was indicated negative and significant to employee performance (β = – 0.253, p=0,004). This study provides prospective insights to management, that mental health is a crucial factor to performance employee to contribution organizational performance.

Implementation of Principal Transformational Leadership and Independent Learning Policy in Improving Education Quality: A Literature Review

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The search ranges from 2015 – 2020. Most of the research results indicate that the principal transformational leadership plays an important role in shaping the quality of education in implementing independent learning education policies. First, the articles reviewed were in English, so other studies were not reviewed due to limitations in the context of several countries. Second, dissertations and theses were not discussed in this article because they could cause publication bias in the results. Third, the scope of the articles reviewed is still limited. Implementation of principal transformational leadership free learning policy in improving the quality of education can be used for various organizations in various countries.

Evaluating Encryption Algorithm Method Based on Software Encryption Tools for Information Security

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Information security is the combination of policies, rules and practices to prevent any unauthorized access or attacks that causes corruption to data, information, and computing services. Information security techniques and programs are built around the core objective to secure data and information by adapting encryption algorithms methods. Encryption algorithm methods impeded in the information security programs or encryption software tools enforce more security by encrypting and decrypting data and information. Encryption algorithm methods are based on algorithms that scramble data and information by converting them into unreadable text. There are various encryption methods used in various encryption software tools. The more encryption algorithm methods used within the encryption software tool, the more security provided on data and information effective data and information security.  In this paper, the most used encryption algorithm methods are analyzed and evaluated based on their usage in encryption software tools to determine the most encryption algorithm method that is used ensure more security on data and information.

The Differences in Toxicity of Pletekan Leaf Extracts (Ruellia tuberosa L.) and Lime (Citrus auraiflia) on Mortality of Culex sp. Mosquito Larvae

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Mosquitoes Culex sp. is the main vector of filariasis. Population control using chemical larvicides continuously can cause resistance. The leaves of the pletekan plant (Ruellia tuberosa L.) and lime fruit (Citrus aurantifolia) have the potential as natural larvicides. This study aims to determine the differences in high toxicity (LC50) of pletekan leaf extract and lime fruit on the mortality of Culex sp. mosquito larvae with an exposure time of 24 hours. Pletekan leaf extract and lime fruit were extracted by maceration using 97% ethanol. The LC50 can use probit analysis with SPSS applications. The results showed that pletekan leaves were toxic to Culex sp. mosquito larvae with an LC50 value of 710.169 ppm with the lowest concentration of 615.231 ppm and the highest concentration of 796.157 ppm. The LC50 value of lime fruit extract was 1026.749 ppm, with a lower limit of 846.406 ppm and an upper limit of 1294.531 ppm.

Talent Readiness of PT KAI to Face the Era of Change

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PT KAI is the only rail-based transportation company in Indonesia managed by SOEs. The main services offered by PT KAI are transportation for passengers and products, while its non-core business is real estate, and its subsidiaries include six companies offering a wide range of services. PT KAI is currently undergoing changes that can be seen with the change in partnership PT KAI is moving towards Global Partnership. This can be seen by the cooperation carried out by PT KAI with other countries in carrying out the Indonesian Fast Train project. One of PT KAI’s missions is to become digital-based railway transportation. This mission is a business response to changes moving into the digital era.

This research was conducted using quantitative methods. Data collection was carried out by researchers by visiting PT KAI Head Office located on Jl. Perintis Kemerdekaan No.1, Babakan Ciamis, Kec. Sumur Bandung, Bandung City, West Java, and PT KAI Training Center located in two locations, namely Jl. Kacapiring, Batununggal District, Bandung City, West Java, Indonesia, and Jl. Ir. H. Juanda No.215, Dago, Coblong District, Bandung City, West Java, Indonesian. The respondents of this study were active employees of PT KAI totaling 168 respondents. The method of data collection is carried out by du event, namely Quick Count or Pooling Priority, and also through Questionnaires. The data processed then was from 140 respondents. The data reduction was carried out because it was found that there were outliers of 28 respondents or 16.67% obtained through examination with the  SPSS 26 tool with the Casewise Diagnostic method.

Researchers also provide solutions to change issues so that PT KAI is better prepared to face the era of change in the future,  consist of PT KAI Goes International through English Habits, and Work Abroad Opportunities for PT KAI’s Top Talent, Transforming Service Quality and Security by maximizing the use of AI and Renewable Technology in all Business processes, Creating Synergies (Including SOEs) through harmonious and collaborative strategic alliances with other state-owned companies, Global Partnership as the best transportation ecosystem solution for Indonesia by opening up to the existence of a Global partnership business scheme.

Super Glue Production by Dermatophytes: Review

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Dermatophytosis can be caused on by the invasion and infection of keratinized tissues in people and animals via a group of filamentous fungus known as dermatophytes. About a quarter of the world’s population is affected by it which is one of the most prevalent superficial fungal diseases.  Some of these fungi have the capacity to develop complex 3-D biofilm structures, or “biofilm,” which are distinguished by the creation of extracellular polymeric molecules and a heightened drug resistance. The assessment of biofilm now relies on a variety of different methods, which frequently results in various evaluations of the microbial strains’ capacity to create biofilms.

It has only recently been discovered the architecture and growth features of dermatophytic biofilms (Trichophyton spp., Microsporum spp.). Additionally, the structural complexity and lack of research on filamentous fungal biofilms make therapy challenging. Therefore, there is a demand for newer antifungals or methods for treating resistant dermatophytosis to offer an efficient, original, and safe substitute to current treatments. Therefore, this review highlighted on the significance, characterization and evaluation of biofilm that produced from dermatophytes.

 

Implementation of Pancasila Ideology in Indonesian Educational Leadership: A Literature Review

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Pancasila plays an important role in responding to the times because the basic values ​​of Pancasila can be developed in the life of the Indonesian nation. Pancasila is the basis of the Republic of Indonesia which is used as a reference in the nation and state. Pancasila as the foundation of nationality and state administration can be used as a solution to solve complex problems in terms of economic, social, political, cultural, educational, defense and security dimensions. The actualization of Pancasila values ​​needs to be socialized, internalized and strengthened in its implementation, in the practice of national and state life by strengthening the character of the nation’s generation in participating in building public understanding of national awareness. The Indonesian state needs a leader who can carry out his vision based on the values ​​of Pancasila as a unifying tool for the nation. The values ​​contained in the Pancasila ideology can be used as the basis for Indonesian education leadership. The values ​​contained in Pancasila, whether God, Humanity, Unity, Consensus, and Justice, must be practiced and applied in the life of the nation, state and society in order to achieve the goals of education in Indonesia. Pancasila-characterized leadership will be able to guide the community towards the ideals of the state, and can be an intermediary in uniting the nation, and instilling the values ​​of Pancasila in the Indonesian people.