Role of TNF-α in Periodontal Disease & Its Implication on Systemic Health

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Periodontal disease is a polymicrobial infection, characterized by gingival inflammation, pocket formation, loss of connective tissue attachment and supporting alveolar bone. Though the etiology of periodontal disease has been established and micro-organisms have been implicated, pathology of these inflammatory lesions have been attributed not only to bacterial products, that have adverse effects on the tissues, but also to chemical mediators released by the host cells, as a result of inflammatory and immune reactions. Oral micro- organisms trigger the endogenous pathways of tissue degradation by activating host cells to produce and release inflammatory mediators and cytokines. These inflammatory mediators and cytokines manifest potent pro-inflammatory and catabolic activity and may play a key role in local amplification of the immune response as well as in periodontal tissue breakdown
Apart from playing an important role in periodontal destruction, systemic elevation of TNF-α levels is extremely toxic to the host and hence has been termed as the “Suicide hormone”. TNF-α, has been postulated to mediate wasting during chronic infections. This review aims to explore the role of TNF-α in periodontal disease & its implication on systemic health.

Identification and Conformation of Bromadiolone Using HPLC and Molecular Dynamics Simulations

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Rodenticides of warfarin group are mainly consisting of bromadiolone(3-(3-(4′-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl)-4-hydroxycoumarin), 3-bromofuran, zinc phosphide etc., having different chemical composition which are frequently used for attempting suicide, perpetrating homicide, accidental inhalation of human being while baiting rats, birds, rabbits in agricultural fields. Bromadiolone, strong and long-acting rodenticide, having anticoagulant properties and also acting as antagonist by disrupting the normal blood clotting mechanisms to vitamin-K, required for blood clotting, and increasing the bleeding tendency in rodents has been taken for finding its reaction mechanisms with different solvent media. The main symptoms of the bromadiolone rodenticides are dizziness, unsteady gait, and abnormal behavior. In the present study, we focused to determine the presence of Bromadiolone in ppm level using HPLC, the reaction mechanism of functional groups (ketone, alcohol, phenol) present in the bromadiolone under the solvent media such as H2O and HCl. The software, Avogadro, has been used to dynamically simulate the Bromadiolone for calculating its optimum energy and to conform the molecular structure under the influence of the water molecule. The reaction mechanism of functional groups in the bromadiolonecombined with the MD simulations may through light to reveal the enzymes activity in damaging the central nervous system which led to fatal.

Mediation Role of Consumer Satisfaction, Consumer Experience, Price Perception, Quality of Service and Brand Image on Repurchasing Interest (Study at Empal Gentong Restaurant H. Apud Cirebon)

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The purpose of this study was to analyze the role of consumer satisfaction in mediating consumer experience, price perception, service quality and brand image on repurchase intention (case study of Empal Gentong H. Apud). The study involved 151 consumers of empal gentong H. Apud who had bought at least once in three months and were in the Cirebon area. Researchers used Partial Least Square (PLS) as a technique used to analyze measurements and structural models. This type of research is descriptive quantitative with the method used is a direct survey and using google form and the results of this study indicate that three variables have a positive and significant effect while the other five variables have a positive and insignificant effect and the last one has a negative and insignificant effect.

Primitive Splenic Lymphoma: A Case Report and Review of the Literature

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Malignant lymphomas are defined as malignant proliferations developed from constituents of lymphoid organs, but also from lymphoid formations contained in most organs (liver, kidneys, digestive) without blood contamination. Lymphoma is a set of monoclonal tumor proliferations developed at the expense of lymphocytes. Lymphoma is the most common malignant tumor of the spleen, but primary lymphoma of the spleen remain an exceptional presentation.

Imaging, Endoscopic and Surgical Aspects Correlation of Inflammatory Bowel Disease: A Retrospective Perspective

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Chronic inflammatory bowel disease have been the major focus of research in gastroenterology these late years. It is due to the elevated incidence of comorbidity as well as complications. MRI, endoscopy as well as histology are the three pillars of the diagnosis, follow-up and prognosis of these pathological entities. Our aim for this study was to determine the relationship between the radiologic, endoscopic modalities and the histological severity of the active disease.

Abdominal Distension after Myomectomy: A Case Report

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We report the case of a 43-year-old woman who had a laparoscopic uterine fibroid resection, admitted for rapid progressive abdominal distention, and for whom MRI and histological examination confirmed the diagnosis of diffuse peritoneal leiomyomatosis. This begnin pathology is rarely described in the literature and its knowledge and important because of the pseudotumoral morphological appearance.

Chronic Constipation Revealing Geophagia: A Case Report

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Geophagia is a frequent cause of chronic constipation. It is often associated with iron-deficiency anemia, which may be the cause. We describe the case of a 4 year-old suffering from a chronic constipation. In which the radiographic examination revealed the presence of sand like stools and thus making an orientation for geophagia. This article come as a reminder of the utility of radiographic examination as a first line abdominal exploration in case of abdominal symptoms.

Attitude of Organic and Inorganic Farmers on Indian Culture – A Comparative Study

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Culture is the reflection of customs, belief, knowledge, art, etc of an individual or a group living in a society. Culture was learnt or formed through socialization. It is considered as a set of knowledge passed on over time. Different cultures serves as a form of guideline or base for the behavior or code of conduct for its followers, thus in a way influenced the way of thinking and acting. Expressive forms involved in a culture like art, rituals, customs are also a representation of a particular set of people. Various civilizations from across the globe practiced or created different cultures which were passed on the next generations. Farming community in general has practiced culture involving safeguarding women, worshipping nature etc. The present study deals with the opinion of organic and inorganic farmers on Indian culture, safeguarding and protecting women, influence of western culture on youngsters and western culture penetration.

Frequency Response of Electronically Tunable Current-Mode Third Order High Pass and Low Pass Filter for Q = 10

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The circuits using current-mode (CM) building blocks have received considerable attention in many filtering and signal processing applications. Compared to their voltage-mode(VM) counterparts, the current-mode building blocks are attractive because of their wider bandwidth, higher slew rate, and lower power consumptions. In IC technology, it is desirable to operate circuits at low voltages which can be achieved by using CM building blocks. As a large number of op-amp based circuits with elegant realization procedures are already available, it is worthwhile to convert them into the circuits based on current-mode building blocks. In this paper, a realization of a current mode third order high pass and low pass filter is described. The proposed circuit employs operational amplifier as the basic building unit. The filter circuit realizes quadratic work function. It provides electronically tuning capability of the filter characteristics. The proposed circuit works ideal for Center frequency fo= 10 k and Circuit merit factor Q > 1. The gain roll-off this configuration is 18dB/octave. The circuit is suitable for monolithic integration and high frequency operation. The filters developed were successful in obtaining passive sensitivities less than unity in magnitude and active sensitivities are half in magnitude, which is a noteworthy achievement. The circuit is suitable for high frequency operation and monolithic integration.

Effect of Covid-19 on Logistics of Thai Rice Export

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The purpose of this paper is to analyze the effects of Covid-19 on Rice Logistic to Thai rice export in terms of product and logistics. Starting from rice plantation, farmers, mills, labour, storage and transportation. In the later part, discusses the impacts of Covid-19 to Thai Rice Export Logistics with conclusion. The authors review Covid-19situation in Thailand and Thai Rice papers. Followed by in-depth interviews influencers and experts from major Rice exporters, Rice Traders and Shipping Lines. The disruption from COVID-19 to Thai rice export logistics was from global supply chain disruption. Imbalance in world containers caused lacking of containers to export and increased Sea Freight were the major effects. High Sea Freight let to higher imported fertilizer cost for plantation. Shipping lines delayed calling some ports in Thailand. Traders delayed the order and waited for lower freight reflecting excess stock in the warehouse. Not only increased cost for carrying stock but also no space for new crop that linked to supply chain disruption as a whole. This paper studied the impacts from 2nd wave of Covid-19 pandemic (2019 to May 2021) in Thailand to Thai Rice logistics where the output could definitely be adopted for further strategy and further study.