Title : Mechanistic Basis of Arsenic Induced Carcinogenesis: Differential miRNA Expression

Vol 6 No 2 (2023): Volume 06 Issue 02 February 2023

Article Date Published : 24 February 2023 | Page No.: 1599-1617 | Google Scholar | Crossref doi for this article

Abstract :

Arsenic, a toxic metalloid, provokes many detrimental consequences to human health. It is prevalent in earth’s crust and poses a major threat to humans globally. Inorganic arsenic exposure occurs mainly via drinking water or food and is metabolized in mammals to form organic metabolites/ end products. Chronic exposure to arsenic causes lung, skin and urinary bladder cancers and increases the risks of liver, kidney and prostate cancers. Arsenic-induced ROS generation, disturbances in several signaling pathways, DNA repair inhibition, chromosomal aberrations, and epigenetic changes including alterations in DNA methylation, histone modifications and differential miRNA expression profiles are involved in cancer progression, and malignant transformation. However, details of arsenic-induced carcinogenesis and molecular mechanisms involved are still remaining obscure. MicroRNAs are post-transcriptional gene expression regulators and themselves may act as oncogenes and tumor suppressor genes. Differential miRNA expression is implicated in several human cancers. This review covers general mechanistic basis of arsenic-induced carcinogenesis, explores recent in-vitro, in-vivo and cohort studies on differential miRNA expression profiles and shares associated molecular mechanistic data on miRNA dysregulation and their functional consequences leading to arsenic induced tumorigenesis, metastasis and cancer, also discusses the future directions.

Keywords :

Arsenic, carcinogenesis, in-vitro and in-vivo studies., miRNA dysregulation, molecular mechanisms

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Author's Affiliation

   Placheril J. John
Professor, Department of Zoology, University of Rajasthan, Jaipur-302004 India

   Navneet Kumar
Centre for advanced studies, Department of Zoology, University of Rajasthan, Jaipur, India – 302004

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Placheril J. John, Navneet Kumar, 2023

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Mechanistic Basis of Arsenic Induced Carcinogenesis: Differential miRNA Expression. Placheril J. John, Navneet Kumar, 6(2), 1599-1617. Retrieved from https://ijcsrr.org/single-view/?id=9430&pid=8957

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