Abstract :

Background: Comorbid diseases are a risk factor for atherosclerosis in coronary heart disease (CHD). Atherosclerosis causes the narrowing of the coronary arteries so that the heart muscles lack blood supply. Diagnostic coronary angiography is an invasive medical examination performed to determine the presence of coronary artery stenosis and to show the location and the number of coronary artery stenosis.

Objective: This study aimed to analyze the characteristics of coronary artery stenosis based on comorbidities of patients with CHD undergoing coronary angiography.

Methods: This analytical study was conducted using a cross-sectional design of 105 patients with CHD undergoing coronary angiographyat the catheterization laboratory at Bahteramas Hospital, Southeast Sulawesi, from January 1 to December 31, 2021.Statistical testing used Chi-squaretests with 95% confidence interval and significance set as p<0.05.

Results: Most of the respondents were over 45 years old as many as 87 (82.9%), and most are male as many as 72 (68.6%). The category of the highest number of stenosis was less than two stenosis, namely 70 patients (66.7%) with the most common location as the  Left Anterior Descending. The comorbidities category included a history of dyslipidemia in 41 people (39.0%), history of diabetes mellitus (DM) in 28 people (26.7%), and history of hypertension in 75 people (71.4%).The bivariate analysis showed a history of DM was associated with coronary artery stenosis (p-value = 0.007) with an Odds Ratio of 3.111.

Conclusions: Patients with DM have 3.111 times greater possibility of developing stenosis of the coronary arteries.WC:246

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Keywords :

Arterial stenosis, co-morbid diseases, Coronary angiography, Coronary heart disease, diabetes mellitus

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References :

1. Harselia SA, Putri AK. Tindakan Percutaneous Coronary Intervention Pada Pasien Stenosis Arteri Koroner Kanan. ARKAVI [Arsip Kardiovask Indones. 2018;3(1):186–91.
2. Huma S, Tariq R, Amin Dr. F, Mahmood Dr. KT. Modifiable and non-modifiable predisposing risk factors of myocardial infarction -A review. J Pharm Sci Res. 2012;4(1):1649–53.
3. Ghani L, Susilawati MD, Novriani H. Faktor Risiko Dominan Penyakit Jantung Koroner di Indonesia. Bul Penelit Kesehat. 2016;44(3):153–64.
4. Ginting ADB. Karakteristik Penyakit Jantung Koroner yang Dilakukan Coronary Artery Bypass Graft di Rumah Sakit Umum Pusat Haji Adam Malik Medan pada Tahun 2015-2016. 2017.
5. Liu Q, Si F, Liu Z, Wu Y, Yu J. Association between triglyceride ‑ glucose index and risk of cardiovascular disease among postmenopausal women. Cardiovasc Diabetol [Internet]. 2023;1–8. Available from: https://doi.org/10.1186/s12933-023-01753-3
6. Zibaeenezhad MJ, Mohammadi SS, Sayadi M, Khorshidi S, Bahramali E, Razeghian-Jahromi I. The impact of diabetes mellitus and hypertension on clinical outcomes in a population of Iranian patients who underwent percutaneous coronary intervention: A retrospective cohort study. J Clin Hypertens. 2019;21(11):1647–53.
7. Shemesh E, Zafrir B. Coronary angiography in the very old: impact of diabetes on long-term revascularization and mortality. J Geriatr Cardiol. 2019;16(1):27–32.
8. Al-Shudifat AE, Johannessen A, Azab M, Al-Shdaifat A, AbuMweis SS, Agraib LM, et al. Risk factors for coronary artery disease in patients undergoing elective coronary angiography in Jordan. BMC Cardiovasc Disord. 2017;17(1):1–5.
9. Wangko LC, Budiono B, Lefrandt RL. Angiografi Koroner: Indikasi, Kontraindikasi, Dan Proteksi Terhadap Radiasi. J Biomedik. 2012;4(3):150–5.
10. Bradley SM, Spertus JA, Kennedy KF, Nallamothu BK, Chan PS, Patel MR, et al. Patient selection for diagnostic coronary angiography and hospital-level percutaneous coronary intervention appropriateness: Insights from the national cardiovascular data registry. JAMA Intern Med. 2014;174(10):1630–9.
11. Amarendra G, Makmun LH, Antono D, Dewiasty E. Peran Tindakan Revaskularisasi terhadap Kesintasan Pasien Non ST Elevation Myocardial Infarction (NSTEMI). J Penyakit Dalam Indones. 2014;1(1):24–30.
12. Nasrin S, Cader FA, Haq MM. Clinical and Angiographic Characteristics of Female Patients Undergoing Coronary Angiography in a Tertiary Hospital in Bangladesh. Ibrahim Card Med J. 2019;7(1–2):9–14.
13. Biswas S, Andrianopoulos N, Dinh D, Duffy SJ, Lefkovits J, Brennan A, et al. Association of Body Mass Index and Extreme Obesity With Long-Term Outcomes Following Percutaneous Coronary Intervention. J Am Heart Assoc. 2019;8(21).
14. Atique SM, Shadbolt B, Marley P, Farshid A. Association Between Body Mass Index and Age of Presentation With Symptomatic Coronary Artery Disease. Clin Cardiol. 2016;39(11):653–7.
15. Piché ME, Tchernof A, Després JP. Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. Circ Res. 2020;1477–500.
16. Valensi P, Avignon A, Sultan A, Chanu B, Nguyen MT, Cosson E. Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: A cross-sectional study. Cardiovasc 2016;15(1):1–10.
17. Hedayatnia M, Asadi Z, Zare-Feyzabadi R, Yaghooti-Khorasani M, Ghazizadeh H, Ghaffarian-Zirak R, et al. Dyslipidemia and cardiovascular disease risk among the MASHAD study population. Lipids Health Dis. 2020;19(1):1–11.
18. Abd alamir M, Goyfman M, Chaus A, Dabbous F, Tamura L, Sandfort V, et al. The Correlation of Dyslipidemia with the Extent of Coronary Artery Disease in the Multiethnic Study of Atherosclerosis. J Lipids. 2018;2018:1–9.
19. Mahalle N, Garg M, Naik S, Kulkarni M. Study of pattern of dyslipidemia and its correlation with cardiovascular risk factors in patients with proven coronary artery disease. Indian J Endocrinol Metab. 2014;18(1):48–55.
20. Low Wang CC, Hess CN, Hiatt WR, Goldfine AB. Clinical update: Cardiovascular disease in diabetes mellitus. Circulation. 2016;133(24):2459–502.
21. Nakanishi R, Baskaran L, Gransar H, Budoff MJ, Achenbach S, Al-Mallah M, et al. Relationship of Hypertension to Coronary Atherosclerosis and Cardiac Events in Patients with Coronary Computed Tomographic Angiography. Hypertension. 2017;70(2):293–9.
22. Venuraju SM, Lahiri A, Jeevarethinam A, Cohen M, Darko D, Nair D, et al. Duration of type 2 diabetes mellitus and systolic blood pressure as determinants of severity of coronary stenosis and adverse events in an asymptomatic diabetic population: PROCEED study. Cardiovasc Diabetol [Internet]. 2019;18(1):1–9. Available from: https://doi.org/10.1186/s12933-019-0855-8
23. Zhang JX, Dong HZ, Chen BW, Cong HL, Xu J. Characteristics of coronary arterial lesions in patients with coronary heart disease and hypertension. Springerplus. 2016;5(1).
24. Gupta N, Elnour AA, Sadeq A, Gupta R. Diabetes and Coronary Artery Disease. E-Journal Cardology Pract. 2022;22:43–54.
25. Dehmer GJ, Weaver D, Roe MT, Milford-Beland S, Fitzgerald S, Hermann A, et al. A contemporary view of diagnostic cardiac catheterization and percutaneous coronary intervention in the United States: A report from the CathPCI registry of the national cardiovascular data registry, 2010 through june 2011. J Am Coll Cardiol. 2012;60(20):2017–31.
26. Mandala NA, Widjojo J, Wendra. Gambaran Lokasi Sumbatan Arteri Koroner Berdasarkan Treadmill Test dan Angiografi. 2016;12:53–64.