Abstract :

The process of a solid dissolving in a liquid phase to create a homogenous mixture is known as solubility. A crucial factor in getting the right quantity of drug into the bloodstream to show a pharmacological effect is solubility. The main issue in developing formulations for new chemical entities as well as for the creation of generics is low water solubility. More than 40% of novel chemical entities (NCEs) created in the pharmaceutical sector are essentially water insoluble. For formulation scientists, solubility is a significant challenge. Any medicine that is to be absorbed at the absorption site must be there in solution form. The solubility of pharmaceuticals that are poorly soluble can be improved using a variety of approaches, such as complexation, salt formation, particle size reduction, crystal engineering, salt formation, solid dispersion, and the like. The choice of a solubility-improving technology is influenced by pharmacological properties, absorption sites, and the requirements for the dosage form. This review article’s goal is to improve bioavailability and promote effective absorption.

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Keywords :

Bioavailability, Dispersion, Nanosuspensions, solubility, Supercritical fluid

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References :

1. Patel MSN, Ahmed MH, Saqib M, Shaikh SN;2019, “Chemical Modification: A unique solutions to Solubility problem”. Journal of Drug Delivery and Therapeutics;9(2): 542-546.
2. Nidhi K, Indrajeet S, Khushboo M, Gauri K, Sen DJ. Hydrotropy:2011, “A Promising tool for solubility Enhancement”. International Journal of Drug Development & Research, 2011; 3(2): 26-33.
3. Savjani KT, Gajjar AK, Savjani JK. Drug solubility:2012, “importance and enhancement techniques”. International Scholarly Research Notices;2012.
4. Singh N, Allawadi D, Singh S, Arora S;2013,“Techniques for Bioavailability Enhancement of BCS Class II Drugs: A Review”. International Journal of Pharmaceutical and Chemical Sciences; 2(2): 1092-1101
5. Kasimedu S, Thoppani SR, Pommala N, Orugonda G, Yelamanda J;2015,“A Review on Solubility Enhancement Techniques. J. Compr. Pharma; 2(2): 36-41
6. Yasir M, Asif M, Kumar A, Aggarval A;2010, “Biopharmaceutical classification system: An account”. International Journal of Pharm Tech Research;2(3):1681-90.
7. Sarangi M, Padhi S;2016, “Solid Lipid Nanoparticles A Review”. Journal of Critical Reviews; 3(3): 5-12.
8. Vemula VR, Lagishetty V, Lingala S;2010, “Solubility enhancement techniques”. International Journal of Pharmaceutical Sciences Review and Research, 2010; 5(1): 41–51.
9. Nigade PM, Patil SL, Tiwari SS;2012, “Self-Emulsifying Drug Delivery Systems (SEDDS): A Review”. International Journal of Pharmacy and Biological Sciences; 2(2): 42-52
10. Kadam SV, Shinkar DM, Saudagar RB;2013, “Review on solubility enhancement techniques”. International Journal of Pharmacy and Biological Sciences; 3(3): 462-575.
11. Yadav NK, Shukla T, Upmanyu N, Pandey SP, Khan MA;2018, “Novel application of mixed hydrotropic solubilization technique in the formulation and evaluation of solid dispersion of flupirtine maleate”. Journal of Drug Delivery and Therapeutics; 8(5): 481-488.
12. Kumar S, Singh P;2016, “Various techniques for solubility enhancement: An overview”. The Pharma Innovation;5(1, Part A):23.
13. Patel BB, Patel JK, Chakraborty S, Shukla D;2015, “ Revealing facts behind spray dried solid dispersion technology used for solubility enhancement”. Saudi Pharmaceutical Journal; 23(4): 352-365.
14. Shah R, Eldridge D, Palombo E, Harding I;2015, “Introduction Lipid Nanoparticles: Production, Characterization and Stability”, Springer; 960: 1–7.
15. Patil MS, Godse SG, Saudagar RB;2013, “Solubility Enhancement by Various Techniques: An Overview”. World Journal of Pharmacy and Pharmaceutical Sciences; 2(6): 4558-4572.
16. Dhapte V, Mehta P. Advances in hydrotropic solutions: An updated review. St. Petersburg Polytechnical University Journal: Physics and Mathematics. 2015 Dec 1;1(4):424-35.
17. Sarfraz RM, Bashir S, Mahmood A, Ahsan H, Riaz H, Raza H, Rashid Z, Raza SA, Abrar MA, Abbas K, Yasmeen T. Application of various polymers and polymers based techniques used to improve solubility of poorly water soluble drugs: A review. Acta Pol. Pharm. 2017 Mar 1;74:347-56.
18. Priyanka B. Parekar, Shivraj S. Shivpuje, Vijay V. Navghare, Manasi M. Savale, Vijaya B. Surwase, Priti S. Mane- Kolpe, Priyanak S. Kale. 2022; Polyherbal Gel Development And Evaluation For Antifungal Activity, European Journal of Molecular & Clinical Medicine. 9(03): 5409-5418.
19. Jain AA, Mane-Kolpe PD, Parekar PB, Todkari AV, Sul KT, Shivpuje SS.2022; Brief review on Total Quality Management in Pharmaceutical Industries,International Journal of Pharmaceutical Research and Applications.7(05):1030-1036
20. K. Attar, Pooja P. Dhanawade, Sonali S. Gurav , Prerna H. Sidwadkar , Priyanka B. Parekar , Shivraj S. Shivpuje.2022; Development and Validation of UV Visible Spectrophotometric Method for Estimation of Fexofenadine Hydrochloride in Bulk and Formulation, GIS SCIENCE JOURNAL.9(11): 936-944
21. Apurva S. Belsarkar, Akanksha V. More,Komal T. Sul,Jagruti G Gawali, Priyanka B Parekar.2022; FORMULATION & OPTIMIZATION OF FLOATING DRUG DELIVERY SYSTEM OF ITRACONAZOLE, International Journal of Creative Research Thoughts.10(11): b912- b931
22. Sailesh WJ, Shivraj SS, Liyakat SI.2018, “Development and Validation of Stability Indicating RP-HPLC Method for the Estimation of Simvastatin in Bulk and Tablet Dosage form.” Research Journal of Pharmacy and Technology. 11(4):1553-8.
23. Wadher Shailesh J, Kalyankar Tukaram M, Shivpuje Shivraj S. 2017, “Development and Validation of Stability Indicating Assay Method for Simultaneous Estimation of Amoxicillin Trihydrate and Cloxacillin Sodium In Pharmaceutical Dosage Form By Using RP-HPLC”.World Journal of Pharmaceutical Research, 6(10):1003-1006
24. Arayne MS, Sultana N, Shehnaz H, Haider A.2011 Jan, “ RP-HPLC method for the quantitative determination of Fexofenadine hydrochloride in coated tablets and human serum”. Medicinal chemistry research.20(1):55-61.
25. Vaghela B, Rao SS, Reddy AM, Venkatesh P, Kumar N.2012 Jun, “Identification and characterization of an oxidative degradation product of Fexofenadine hydrochloride, development and validation of a stability-indicating RP-UPLC method for the estimation of process related impurities and degradation products of Fexofenadine hydrochloride in pharmaceutical formulations”, Scientiapharmaceutical,80(2):295-310.
26. Pravin P Karle, Shashikant C Dhawale, VijayVNavghare,ShivrajSShivpuje.2021;OptimizationofextractionconditionsandevaluationofManilkarazapota(L.)P.Royenfruitpeelextractforinvitroα-glucosidaseenzymeinhibitionandfreeradical scavenging potential. Future Journalof Pharmaceutical Sciences, 7(1):1-10.
27. MR Rao, S Shivpuje, R Godbole, C Shirsath.2015;Design and evaluation of sustained release matrix tablet susingsintering technique. International Journal of Pharmacyand Pharmaceutical Sciences, 8(2):115-121.
28. MRP Rao, S Taktode, SS Shivpuje, S Jagtap.2016; Optimization of Transmucosal Buccal DeliveryofLosartanPotassiumusingFactorialDesign.IndianJournalofPharmaceuticalEducationandResearch,50(2): S132-S139.
29. N Patre, S Patwekar, S Dhage, S Shivpuje. 2020; Formulation & Evaluation Of Piroxicam Bionanocomposite For Enhancement of Bioavailability. European Journal of Molecular & Clinical Medicine, 7(11): 9362-9376.
30. SJ Wadher, SL Patwekar, SS Shivpuje, SS Khandre, SS Lamture. 2017; Stability Indicating Assay Methods for Simultaneous Estimation of Amoxicillin Trihydrate And Cloxacillin Sodium in Combined Capsule Dosage Form by UV-Spectrophotometric Method. European Journal of Biomedical and Pharmaceutical sciences, 4(10).
31. Santosh A.Payghan Shivraj S. Shivpuje Shailesh L. Patwekar, Karna B. Khavane, Padmavati R. Chainpure. 2021; A Review on Different Preparation Method Used For Development of Curcumin Nanoparticles. International Journal of Creative Research Thoughts, 9(1):4088-4101.
32. Zeba Ashfaq Sheikh P. R. Chainpure, S. L. Patwekar, S. S. Shivpuje. 2019; Formulation and evaluation of Garciniacambogia and Commiphoramukul Herbal tablets used for Anti- Obesity. International Journal of Engineering, Science and Mathematics, 8(4): 180-195.
33. Sheetal Rathod P. R. Chainpure, S. L. Patwekar, S. S. Shivpuje. 2019; A Study Of Carica Papaya Concerning It’s Ancient And Traditional Uses – Recent Advances And Modern Applications For Improving The Milk Secretion In Lactating Womens. International Journal of Research, 8(2):1851-1861.
34. Shivraj S. Shivpuje Shailesh J. Wadher, Bhagwan B. Supekar. 2019; Development And Validation of New FT-IR Spectrophotometric Method                        For Simultaneous Estimation Of Ambroxol Hydrochloride      And     Cetirizine Hydrochloride In Combined Pharmaceutical. International Research Journal of Pharmacy, 10(3):110-114.
35. Shivraj S. Shivpuje, Shailesh J. Wadher, Bhagwan B. Supekar. 2019; Simultaneous Estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride in Combined Solid Tablet Formulations by HPTLC- Densitometric Method. Asian Journal of Biochemical and Pharmaceutical Research, 9(1):1-10.
36. W Sailesh, SS Shivraj, SI Liyakat. 2018; Development and Validation of Stability Indicating RP-HPLC Method for the Estimation of Simvastatin in Bulk and Tablet Dosage form. Research Journal of Pharmacy and Technology, 11(4): 1553- 1558.
37. Patil S. S. Shivpuje Shivraj S. Patre Narendra G. 2017; Development and Validation Of Stability Indicating HPTLC Method For Determination of Nisoldipine (Niso) In Tablet Dosage Form. European Journal of Biomedical and Pharmaceutical sciences, 4(12):462-468.
38. Lamture Sima S. and Shaikh Isak Wadher Shailesh J., Kalyankar Tukaram M., Shivpuje Shivraj S., Khandre Supriya S. 2017; Development And Validation Of Stability Indicating Assay Method For Simultaneous Estimation Of Amoxicillin Trihydrate And Cloxacillin Sodium In Pharmaceutical Dosage Form By HPTLC. World Journal of Pharmaceutical Research, 10(6):1002-1014.
39. W Shailesh, K Tukaram, S Shivraj, L Sima, K Supriya. 2017; Development and Validation of Stability Indicating UV Spectrophotometric Method   for Simultaneous Estimation of Amoxicillin Trihydrate and Metronidazole In Bulk And In-House Tablet. World Journal of Pharmaceutical and Medical Research, 3(8):312-318.
40. Wadher Shailesh, M Kalyankar Tukaram, S Shivpuje Shivraj. 2017; Development and Validation of Stability Indicating Assay Method for Simultaneous Estimation of Amoxicillin Trihydrate and Cloxacillin Sodium In Pharmaceutical Dosage Form By Using RP-HPLC. World Journal of Pharmaceutical Research, 10(6):1002-1014