Abstract :

Introduction: Autistic disorder, Asperger syndrome and pervasive developmental disorder-not otherwise specified comprise a heterogeneous group of neurodevelopmental disorders known as autism spectrum disorders (ASDs). ASDs are behaviorally defined by impairments in communication and social interaction along with restrictive and repetitive behaviors.

Objectives of the study: The main objectives of the study will determine the mitochondrial dysfunction in autistic individuals by measuring plasma lactate levels.

Material and methods: This cross sectional study was conducted in DHQ Hospital Sahiwal. This study will include 200 children aged 7 to 9 years. Randomly selected sampling technique will be used for the data collection. For the purpose of analysis of mitochondrial dysfunctionality we will collect the blood samples of each individual.

Results: The data was collected from 200 children. In this study, blood ammonia, serum lactate, AST, ALT and CK level were higher in 29(90%), 18(80%), 23 (30%), 20(20%) and 14 (40%) subjects of study group.

Conclusion: It is concluded that mitochondrial dysfunction occur in children with autism spectrum disorder children

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Keywords :

Dysfunction, Health, Mitochondria, Patients

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