Abstract :

Introduction: Oxygen radical injury is thought to be one of the common mechanisms for several diseases in premature infants. Lipid peroxidation plays a vital role in the pathogenesis of many neonatal complications. Broncho pulmonary dysplasia, Intraventricular hemorrhage and Retinopathy of Prematurity are due to excessive production of oxygen free radicals.
Objectives: The main objective of the study is to find the Malondialdehyde (MDA), total antioxidant capacity and Vitamin E levels in preterm and term infants.
Material and methods: We aimed to determine the levels of Malondialdehyde (MDA), Total antioxidant capacity and vitamin E in cord blood of term and preterm infants. To determine the oxidative stress and antioxidants in cord blood of term and preterm infants that may have clinical implications. In the present study we determine MDA, Total antioxidant capacity and vitamin E levels in the umbilical cord blood of term (n=50) and preterm (n=50) infants by manual method. Blood samples were collected during delivery. MDA is high in preterm infants compared to term infants.
Results: Total antioxidant capacity and Vitamin E levels are high in term infants compared to preterm infants. Therefore it is possible to postulate that preterm infants are more susceptible to oxidative stress than term infants.
Conclusion: It is concluded that Preterm neonates are exposed to increased oxidant stress at birth and are susceptible to anti-oxidant deficiencies.

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Keywords :

Antioxidant, Infants, MDA, TAC

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References :

1. Burton GJ, Jauniaux E. Oxidative stress, Best Practice & Research Clinical Obstetrics and Gynaecology. 2010; doi: 10. 1016.
2. Finer N, Leone T. Oxygen saturation monitoring for the preterm infant: the evidence basis for current practice. Pediatr Res 2009; 65(4):375-380.
3. Maulik D, Zanelli S, Numagami Y, Ohnishi ST, Mishra OP, Delivoria PM. Oxygen free radical generation during in-utero hypoxia in the fetal guinea pig brain: the effects of maturity and of magnesium sulfate administration. Brain Res. 1999; 817: 117-22.
4. Abdel Ghany EA, Alsharany W, Ali AA, Youness ER, Hussein JS. Anti-oxidant profiles and markers of oxidative stress in preterm neonates. Paediatr Int Child Health. 2016 May;36(2):134-40. doi: 10.1179/2046905515Y.0000000017. Erratum in: Paediatr Int Child Health. 2017 Aug;37(3):ei. Younass, Eman Rafaat [Youness, Eman Refaat]. PMID: 25940692.
5. L Slater, Y Asmerom, DS Boskovic, Plank MS Bahjri, KR Angeles, et al. Procedural pain and oxidative stress in premature neonates J Pain, 13 (2012), pp. 590-597
6. Suhail M, Faizul-Suhail M. Maternal and cord blood malondialdehyde and antioxidant vitamin levels in normal and preeclamptic women. Biochem Med (Zagreb). 2009;19:182-191
7. Gupta, P., Narang, M., Banerjee, B. et al. Oxidative stress in term small for gestational age neonates born to undernourished mothers: a case control study. BMC Pediatr 4, 14 (2004). https://doi.org/10.1186/1471-2431-4-14
8. Negi R, Pande D, Kumar A, Khanna RS and Khanna HD: Evaluation of biomarkers of oxidative stress and antioxidant capacity in the cord blood of preterm low birth weight neonates. J Matern Fetal Neonatal Med. 25:1338–1341. 2012
9. Özalkaya E, Karatekin G, Topcuoglu S, Karatepe HO, Hafızoglu T, Baran P and Ovalı F: Neonatology oxidative status in preterm infants with premature preterm rupture of membranes and fetal inflammatory response syndrome. Pediatr Neonatol. 58:437–441. 2017
10. Menon R and Richardson LS: Preterm prelabor rupture of the membranes: A disease of the fetal membranes. Semin Perinatol. 41:409–419. 2017.
11. İlhan N, Aygun BK and Gungor H: The relationship between the latency period, infection markers, and oxidant and antioxidant states in women with preterm premature rupture of membranes. Ir J Med Sci. 186:965–970. 2017.
12. Matyas, M., & Zaharie, G. (2019). Antioxidants at Newborns. In (Ed.), Antioxidants. IntechOpen.
https://doi.org/10.5772/intechopen.85175