Abstract :
Major depressive disorder (MDD) is a major psychiatric condition associated with functional impairment and high levels of morbidity and mortality (M. Li, 2015) (Lohoff, 2010). It is characterized by mode alterations, diminished interests, impaired cognitive function and vegetative symptoms such as disturbed sleep and appetite changes (Christian Otte, 2016) are common patients suffering from MDD. Our nervous system is built around the balance and harmony of two opposing activities (Laurie Kelly McCorry, 2007).
1. The sympathetic nervous system (SNS) is associated with the fight or flight response.
2. The parasympathetic nervous system (PNS) is associated with relaxation, digestion, and regeneration.
These two systems are meant to work in rhythmic alternation, a process that supports healthy rhythms of alertness and restfulness that facilitate physical and mental health (Shah, 2018). In order to treat ailments such as MDD, many techniques are used to stimulate the vagus nerve for better functioning (Bruno Bonaz, 2018). Different forms of pranayama tends to activate different branches of the autonomic nervous system, this causes positive changes to the oxygen consumption, metabolism and skin resistance. The literature evidence gathered states that the mechanisms of the vagul nerve stimulation helps in the parasympathetic activation in an event of stress depression and major depression. When the pranayam is mixed with certain yogic asana’s while controlling the breath, it seems to have a better countering of MDD and related disorders.
Keywords :
Major Depressive Disorder, Parasympathetic Nervous System, Pranayama, Vagus Nerve, Yoga AsanaReferences :
1. Alan W C Yuen, J. W. (2017). Can natural ways to stimulate the vagus nerve improve seizure control? epilepsy and behavior , 105-110.
2. Anette Kjellgren, c. a. (2007). Wellness through a comprehensive Yogic breathing program – A controlled pilot trial. BMC Complement Altern Med.
3. apa. (2018, 11 01). apa.org/topics/stress/body. Retrieved 10 04, 2021, from
www.apa.org: https://www.apa.org/topics/stress/body
4. Bruno Bonaz, T. B. (2018). The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. frontiers of neuroscience, doi: 10.3389/fnins.2018.00049.
5. Christian Otte, S. M. (2016). Major depressive disorder. 2 (16065 ).
6. Chu, B., Marwaha, K., Sanvictores, T., & Ayers., D. (2021). Physiology, Stress Reaction. statpearls .
7. E. Sankaranarayanan, P. P. (2006). Effect of deep breathing at six breaths per minute on the frequency of premature ventricular complexes. international journal of cardiology , 450-452.
8. Ghodarz Akkasheh, Z. K.-P.-E. (2016). Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Nutrition , 315-320.
9. Giuseppe Grosso, F. G. (2014). Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms. Oxidative Medicine and Cellular Longevity.
10. Grant Soosalu, S. H. (2019). Head, Heart, and Gut in Decision Making: Development of a Multiple Brain Preference Questionnaire. SAGE journals , doi.org/10.1177/2158244019837439.
11. Jahnke, R. L. (2010). A comprehensive review of health benefits of Qigong and Tai Chi. J. Health Promot .
12. KABEL, O. (2016, 03 25). yogauonline.com/yoga-anatomy/how-can-we-stimulate-vagus-nerve-our-yoga-practice-part-1. Retrieved 10 04, 2021, from yogauonline.com: https://yogauonline.com/yoga-anatomy/how-can-we-stimulate-vagus-nerve-our-yoga-practice-part-1.
13. Kim, E. W.-K. (2016). Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression. current neuropharmachology , 665-673.
14. Kishore Kumar Katuri, A. B. (2016). Association of yoga practice and serum cortisol levels in chronic periodontitis patients with stress-related anxiety and depression. journal of internation societyof preventive and community dentistry , 7-14.
15. Komori, T. (2018). The relaxation effect of prolonged expiratory breathing. mental illness journal.
16. Kozasa, E. H.-S. (2008). Evaluation of Siddha Samadhi Yoga for Anxiety and Depression Symptoms: A Preliminary Study. Psychological Reports, 103(1), , 271-274.
17. Kristin Schmidt, P. J. (2015). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology (Berl). , 1793–1801.
18. Laurie Kelly McCorry, P. (2007). Physiology of the Autonomic Nervous System. American Journal of Pharmaceutical Education , article 78.
19. Lívea Dornela Godoy, M. T.-P.-C. (2018). A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications. frontiers in behavioral neroscience , https://doi.org/10.3389/fnbeh.2018.00127.
20. Lohoff, F. W. (2010). Overview of the Genetics of Major Depressive Disorder. 12.
21. M. C., T. D. (2017). Mindfulness mediates the physiological markers of stress: systematic review. journal of psychiatry research , 156-178.
22. M. Li, C. D. (2015). Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions. 46 (4).
23. Maheshkumar Kuppusamy, c. a. (2016). Immediate Effects of Bhramari Pranayama on Resting Cardiovascular Parameters in Healthy Adolescents. journal of clinical and diagnostic research , cc17-cc19.
24. Manjunath Nandi Krishnamurthy, S. T. (2007). Assessing depression following two ancient Indian interventions: effects of yoga and ayurveda on older adults in a residential home. mubmed , 17-23.
25. Manuela Jungmann, B. M.-P. (2018). Effects of Cold Stimulation on Cardiac-Vagal Activation in Healthy Participants: Randomized Controlled Trial. JMIR form Research .
26. Marc A. Russo, D. M. (2017). The physiological effects of slow breathing in the healthy human. breathe , 298-309.
27. Maria Ines Pinto-Sanchez, G. B.-P. (2017). Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. gastroenterology aga , 448-459.
28. Martina Corazzol, G. L.-O. (2017). Restoring consciousness with vagus nerve stimulation. current biology , r994-r996.
29. Matthew J Watt, K. F. (2001). Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans. journal of physiology , 269-278.
30. Maurizio Fava, K. S. (2000). Major Depressive Disorder. Neuron Vol. 28.
31. Michaël Messaoudi, N. V.-F. (2011). Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut microbes , 256-261.
32. MISHRA, D. A. (2013). EFFECT OF 16 WEEKS YOGIC INTERVENTION IN. International Journal of Pharma and Bio Sciences, 207-212.
33. Morgana M. Novaes, F. P.-F.-S.-S. (2020). Effects of Yoga Respiratory Practice (Bhastrika pranayama) on Anxiety, Affect, and Brain Functional Connectivity and Activity: A Randomized Controlled Tria. frontiers in psychiatry .
34. N. Janakiramaiah, B. G. (2000). Antidepressant efficacy of Sudarshan Kriya Yoga (SKY) in melancholia: a randomized comparison with electroconvulsive therapy (ECT) and imipramine. Journal of Affective Disorders , 255-259.
35. Nemati, A. (2013). The effect of pranayama on test anxiety and test performance. international journal of yoga , 55-60.
36. Pandey S, M. N. (2010). Role of self-induced sound therapy: Bhramari Pranayama in Tinnitus. talor and francis , 137-141.
37. Pinkesh, D. P. (2020). The Effect of Pranayama on Stress and Depression in College Female Students. international journal of advance sceince and technology .
38. RavinderJerath, J. W. (2006). Physiology of long pranayamic breathing: Neural respiratory elements may provide a mechanism that explains how slow deep breathing shifts the autonomic nervous system. medical hypothesis , 566-571.
39. Richard P Brown, P. L. (2005). Sudarshan Kriya Yogic breathing in the treatment of stress, anxiety, and depression. Part II–clinical applications and guidelines. alternative complementary medicine , 711-717.
40. Sanjeev Rampalliwar, C. R. (2013). The effect of Bhramari pranayama on pregnant women having cardiovascular hyper -reactivity to cold pressor test. national journal of phisiology pharmacy and pharmacology , 137-141.
41. Schacky, C. v. (251-262). A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels. vascular health risk managment , 2006.
42. Shah, S. (2018, 07 30). Art of Living . Retrieved 10 03, 2021, from copyright Art of Living : https://www.artofliving.org/in-en/lifestyle/happiness/7-natural-ways-to-strengthen-and-stimulate-your-vagus-nerve-today
43. Shan Liang, X. W. (2018). Recognizing Depression from the Microbiota–Gut–Brain Axis. international journal of molecular science , doi: 10.3390/ijms19061592.
44. Sigrid Breit, A. K. (2018). Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders. Frontiers in Psychiatry
45. Soraya Seedat, P., Kate Margaret Scott, P., Matthias C. Angermeyer, P., & Patricia Berglund, M. (2009). Cross-National Associations Between Gender and. 66 (7).
46. Sylvain Laborde, E. M. (2017). Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research – Recommendations for Experiment Planning, Data Analysis, and Data Reporting. forntiers of psychology , doi.org/10.3389/fpsyg.2017.00213.
47. V R Hariprasad, P. T. (2013). Effects of yoga intervention on sleep and quality-of-life in elderly: A randomized controlled trial. Indian J Psychiatry , 64-68.
48. Weili Chan, M. A. (2012). Yoga and exercise for symptoms of depression and anxiety in people with poststroke disability: a randomized, controlled pilot trial. alternate health medicine , 34-43.
49. Wood, T. (2017, 12 27). tiffanywoodyoga.com/blog/meet-your-vagus-nerve. Retrieved 10 04, 2021, from
tiffanywoodyoga: https://tiffanywoodyoga.com/blog/meet-your-vagus-nerve
50. Xiao Ma, Z.-Q. Y.-Q.-Y.-T.-X.-F. (2017). The Effect of Diaphragmatic Breathing on Attention, Negative Affect and Stress in Healthy Adults. fontiers in psychology .