Abstract :

Gastroenteritis, commonly referred to as stomach flu, is an acute inflammation of the gastrointestinal tract, marked by symptoms including diarrhea, vomiting, abdominal cramps, and fever. This review article provides a comprehensive overview of gastroenteritis, addressing its etiology, epidemiology, pathophysiology, diagnosis, management, and prevention strategies. The condition is caused by a variety of infectious agents such as viruses (noroviruses, rotaviruses), bacteria (Campylobacter, Salmonella), and parasites (Giardia lamblia), with transmission typically occurring through contaminated food, water, or person-to-person contact. Globally, gastroenteritis remains a significant public health issue, with high morbidity and mortality rates, particularly in children under five in developing countries. Diagnosis often relies on clinical evaluation and laboratory tests, while management focuses on rehydration therapy and symptomatic relief. Preventive measures include personal hygiene, food safety practices, environmental sanitation, and vaccination, with rotavirus vaccines significantly reducing severe cases in children. Emerging trends in gastroenteritis research aim at developing rapid diagnostic tools, novel therapeutic approaches, and new vaccines, highlighting the importance of a multidisciplinary approach to mitigate the global impact of this disease.

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Keywords :

diagnosis, Management, Pathophysiology, Prevention., Stomach flu.

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References :

1. Guerrant, L., Walker, D. H., & Weller, P. F. (Eds.). (2011). Tropical Infectious Diseases: Principles, Pathogens and Practice (3rd ed.). Elsevier Saunders.
2. Koo, L., Ajami, N., Atmar, R. L., & DuPont, H. L. (2010). Noroviruses: The leading cause of gastroenteritis worldwide. Discovery Medicine, 10(50), 61-70.
3. World Health (2017). Diarrhoeal disease. https://www.who.int/news- room/fact- sheets/detail/diarrhoeal-disease
4. Payne, D. C., Vinjé, J., Szilagyi, P. G., Edwards, K. M., Staat, M. A., Weinberg, G. A., … & Parashar, U. D. (2013). Norovirus and medically attended gastroenteritis in U.S. children. New England Journal of Medicine, 368(12), 1121-1130.
5. Kotloff, K. L., Nataro, J. P., Blackwelder, W. C., Nasrin, D., Farag, T. H., Panchalingam, , … & Levine, M. M. (2013). Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. The Lancet, 382(9888), 209-222.
6. Glass, R. I., Parashar, U. D., & Estes, M. (2009). Norovirus gastroenteritis. New England Journal of Medicine, 361(18), 1776-1785.
7. Guerrant, R. , Van Gilder, T., Steiner, T. S., Thielman, N. M., Slutsker, L., Tauxe, R. V.,
8. … & Tarr, I. (2001). Practice guidelines for the management of infectious diarrhea. Clinical Infectious Diseases, 32(3), 331-351.
9. Checkley, , White, A. C., Jaganath, D., Arrowood, M. J., Chalmers, R. M., Chen, X. M.,
10. … & Cravioto, (2015). A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for Cryptosporidium. The Lancet Infectious Diseases, 15(1), 85-94.
11. Lopman, B., Gastañaduy, P., Park, G. W., Hall, A. J., Parashar, U. D., & Vinjé, J. (2012). Environmental transmission of norovirus gastroenteritis. Current Opinion in Virology, 2(1), 96-
12. Newell, D. G., Koopmans, M., Verhoef, L., Duizer, E., Aidara-Kane, A., Sprong, H., … & Kruse, H. (2010). Food-borne diseases—the challenges of 20 years ago still persist while new ones continue to International Journal of Food Microbiology, 139, S3-S15.
13. Kotloff, K. L. (2017). The burden and etiology of diarrheal illness in developing countries. Pediatric Clinics of North America, 64(4), 799-814.
14. Becker, K. M., Moe, C. L., Southwick, K. L., & MacCormack, J. N. (2000). Transmission of Norwalk virus during a football game. New England Journal of Medicine, 343(17), 1223-
15. Troeger, , Khalil, I. A., Rao, P. C., Cao, S., Blacker, B. F., Ahmed, T., … & Mokdad, A.
16. (2018). Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatrics, 172(10), 958-965.
17. Ramig, R. F. (2004). Pathogenesis of intestinal and systemic rotavirus infection. Journal of Virology, 78(19), 10213-10220.
18. Bok, , & Green, K. Y. (2012). Norovirus gastroenteritis in immunocompromised patients. New England Journal of Medicine, 367(22), 2126-2132.
19. Guerrant, L., Van Gilder, T., Steiner, T. S., Thielman, N. M., Slutsker, L., Tauxe, R. V.,
20. … & Tarr, I. (2001). Practice guidelines for the management of infectious diarrhea. Clinical Infectious Diseases, 32(3), 331-351.
21. Fleckenstein, M., Hardwidge, P. R., Munson, G. P., Rasko, D. A., Sommers, H., & Rahme,
22. G. (2010). Molecular mechanisms of enterotoxigenic Escherichia coli infection. Microbes and Infection, 12(2), 89-98.
23. Guerrant, L., Van Gilder, T., Steiner, T. S., Thielman, N. M., Slutsker, L., Tauxe, R. V.,
24. … & Tarr, I. (2001). Practice guidelines for the management of infectious diarrhea. Clinical Infectious Diseases, 32(3), 331-351.
25. Beatty, M. E., Adcock, P. M., Smith, S. W., Quinlan, K., Kamimoto, L. A., Lee, P. A., … & Paralytic Illness Case Working Group. (2006). Epidemic diarrhea due to enterotoxigenic Escherichia coli. Clinical Infectious Diseases, 42(3), 329-334.
26. Guerrant, L., Van Gilder, T., Steiner, T. S., Thielman, N. M., Slutsker, L., Tauxe, R. V., … & Tarr, P. I. (2001). Practice guidelines for the management of infectious diarrhea. Clinical Infectious Diseases, 32(3), 331-351.
27. Humphries, M., & Linscott, A. J. (2015). Laboratory diagnosis of bacterial gastroenteritis. Clinical Microbiology Reviews, 28(1), 3-31.
28. Tolan, J., & Davies, H. O. (2017). Radiology in acute gastroenteritis. Clinical Radiology, 72(8), 621-629.
29. Navidad, J. F., Griswold, D. J., Gradus, M. S., & Bhattacharyya, S. (2013). Evaluation of diarrhea in the emergency Emergency Medicine Clinics, 31(1), 195-214.
30. Guarino, A., Ashkenazi, S., Gendrel, D., Vecchio, A. L., Shamir, R., & Szajewska, H. (2014). European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. Journal of Pediatric Gastroenterology and Nutrition, 59(1), 132-152.
31. Guerrant, L., Van Gilder, T., Steiner, T. S., Thielman, N. M., Slutsker, L., Tauxe, R. V., … & Tarr, P. I. (2001). Practice guidelines for the management
32. Riddle, M. S., DuPont, H. L., & Connor, B. A. (2016). ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. The American Journal of Gastroenterology, 111(5), 602-622.
33. Shane, L., Mody, R. K., Crump, J. A., Tarr, P. I., Steiner, T. S., Kotloff, K., … & Pickering,
34. K. (2017). 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clinical Infectious Diseases, 65(12), e45-e80.
35. Ejemot-Nwadiaro, R. I., Ehiri, J. E., Arikpo, D., Meremikwu, M. M., & Critchley, J. A. (2015). Hand washing promotion for preventing diarrhoea. Cochrane Database of Systematic Reviews, (9).
36. Troeger, , Khalil, I. A., Rao, P. C., Cao, S., Blacker, B. F., Ahmed, T., … & Mokdad, A.
37. (2018). Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatrics, 172(10), 958-965.
38. Centers for Disease Control and Prevention. (2019). Guide to Preventing and Controlling Gastroenteritis Outbreaks in Healthcare Retrieved from https://www.cdc.gov/hai/pdfs/norovirus/229800-A-NoroGuideForHealthCareSettings-ACC.pdf

39. Gregoricus, , Arvay, M., Williams, I., McCall, J., Edmiston, K., Johnson, A., … & Vinjé,
40. (2021). Evaluation of a multiplex molecular panel for detection of viral and bacterial gastroenteritis pathogens. Journal of Clinical Microbiology, 59(9), e00619-21.
41. Rocha-Pereira, , Jochmans, D., Debing, Y., Verbeken, E., Nascimento, M. S., & Neyts,
42. (2013). The viral polymerase inhibitor 2′-C-methylcytidine inhibits norwalk virus replication and favors mutagenesis of the viral RNA. Journal of Virology, 87(13), 7797-7807.
43. Riddle, S., Chen, W. H., Kirkwood, C. D., & MacLennan, C. A. (2018). Update on vaccines for enteric pathogens. Clinical Microbiology and Infection, 24(2), 190-200.