Abstract :
Targeting the drug to a particular site to reduce the drug toxicity requires a special drug delivery system.
Nanosponges are tiny particals with porous cavities to facilitate drug substances. Nanosponges efficiently transport both hydrophilic and lipophilic drug substances the present manuscript focus method of preparation, mechanism of drug release, evaluation and application of nanosponges.
Keywords :
Controlled release, Hydrophilic, Hydrophobic., Nanosponges, Targeted releaseReferences :
- Bolmal UB, Manvi FV, Rajkumar K, Palla SS, Paladugu A, Reddy KR. Recent advances in nanosponges as drug delivery system. Int J Pharm Sci Nanotechnol 2013;6:1934-44.
- Thakre AR, Gholse YN, Kasliwal RH. Nanosponges: a novel approach of drug delivery system. J Med Pharm Allied Sci 2016;78:103-11.
- Rita L, Amit T, Chandrashekhar G. Current trends in βcyclodextrin based drug delivery systems. Int J Res Ayurveda Pharm 2011;2:1520-6.
- Ahmed RZ, Patil G, Zaheer Z. Nanosponges–a completely new nano-horizon: pharmaceutical applications and recent advances. Drug Dev Ind Pharm 2013;39:1263-72.
- Singh D, Soni GC, Prajapati SK. Recent advances in nanosponges as drug delivery system: a review. Eur J Pharm Med Res 2016;3:364-71.
- Jilsha G, Viswanad V. Nanosponges: a novel approach of drug delivery system. Int J Pharm Sci Rev Res 2013;19:119-23.
- Shringirishi M, Prajapati SK, Mahor A, Alok S, Yadav P, Verma A. Nanosponges: a potential nanocarrier for novel drug delivery-a review. Asian Pacific J Trop Disease 2014;4:19-26.
- Nanosponges: A New Approach for Drug Targetting K. Arshad Ahmed, Khan. Int J Pharm Pharm Res 2016;7:381-96.
- Sharma R, Pathak K. Nanosponges: Emerging drug delivery system. Pharma Stud; 2010. p. 33-5.
- Indira B, Bolisetti SS. Nanosponges: a new era in drug delivery. J Pharm Res 2012;5:5293-6.
- Susmitha, Charanjit, V Manisha Reddy, Naveena, V Ram Mohan Gupta. Nanosponges–a concise review of emerging trends. Int J Pharm Res Biomed Anal 2014;3:1-6.
- Challa R, Ahuja A, Ali J, Khar RK. Cyclodextrins in drug delivery: an updated review. AAPS PharmSciTech 2005;6:E329-57.
- Selvamuthukumar S, Anandam S, Krishnamoorthy K, Rajappan M. Nanosponges: a novel class of drug delivery system-review. J Pharm Pharm Sci 2012;15:103-11.
- Trotta F, Dianzani C, Caldera F, Mognetti B, Cavalli R. The application of nanosponges to cancer drug delivery. Expert Opinion Drug Delivery 2014;11:931-41.
- Gidwani B, Vyas A. A comprehensive review of cyclodextrinbased carriers for delivery of chemotherapeutic cytotoxic anticancer drugs. BioMed Res Int 2015;15:1-15.
- Vyas A, Saraf S, Saraf S. Cyclodextrin based novel drug delivery systems. J Inclusion Phenom Macrocyclic Chem 2008;62:23-42.
- Isabelle A, Christine V, Helene C, Elias F, Patrick C. Spongelike Alginate Nanoparticles as a new potential system for the delivery of Antisense Oligonucleotides. Antisense and Nucleic Acid Drug Development. 9(3): 1999; 301-312.
- Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization stability and cytotoxicity. Eur J Pharm Biopharm. 74: 2010; 193-201.
- Rosalba M, Roberta C, Roberto F, Chiara D, Piergiorgio P, Leigh E, Li S, Roberto P. Antitumor activity of Nanosponge – encapsulated Camptothecin in human prostrate tumors. Cancer Res. 71: 2011; 4431.
- Lala R, Thorat A, Gargote C. Current trends in β- cyclodextrin based drug delivery systems. Int J Res Ayur Pharm. 2(5): 2011; 1520- 1526.
- Renuka Sharma, Roderick B. Walker, Kamla Pathak. Evaluation of Kinetics and Mechanism of Drug Release from Econazole nitrate Nanosponge Loaded Carbapol Hydrogel. Ind J Pham Edu Res. 45(1): 2011; 25-31.
- Renuka S, Kamla P. Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation. Pharm Dev Technol. 16(4): 2011; 367-376.
- Shankar S, Vavia PR, Francesco T, Satyen T. Formulation of Betacyclodextrin based nanosponges of Itraconazole. J Incl Phenom Macrocycl Chem. 57: 2007; 89-94.
- Torne SJ, Ansari KA, Vavia PR, Trotta F, Cavalli R. Enhanced oral Paclitaxel bioavailability after administration of Paclitaxel loaded nanosponges. Drug Delivery. 17.(6): 2010; 419-425.
- Ansari KA, Torne SJ, Vavia PR, Trotta F, Cavalli R. Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7 cell line culture. Curr Drug Deliv. 8(2): 2011; 194-202.
- Khalid AA, Pradeep RV, Francesco T, Roberta C. Cyclodextrinbased nanosponges for delivery of Resveratrol: In Vitro characterisation, stability, cytotoxicity and permeation study AAPS PharmSciTech. 12(1): 2011; 279-286.
- Jenny A, Merima P, Alberto F, Francesco T. Role of β-cyclodextrin nanosponges in propylene photooxidation. Carbohydrate Polymers. 86: 2011; 127-135.
- William K, Benjamin S, Eva H. Synthesis and Characterization of Nanosponges for Drug Delivery and Cancer Treatment. www.Vanderbilt.edu . 2011.
- Renuka Sharma, Roderick B. Walker, Kamla Pathak. Evaluation of Kinetics and Mechanism of Drug Release from Econazole nitrate Nanosponge Loaded Carbapol Hydrogel. Ind J Pham Edu Res. 45(1): 2011; 25-31.
- Martin A, Swarbrick J, Cammarrata A. In: Physical Pharmacy – Physical Chemical Principles in Pharmaceutical Sciences. 3: 1991; 527.
- K. Patel, R.J. Oswal. Nanosponge and Microsponges: A Novel Drug Delivery System. IJRPC. 2(2): 2012; 237-244.
- Wester R, Patel R, Natch S, Leyden J, Melendres J, Maibach H. Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy. J Am Acad Derm. 24: 1991; 720-726.
- Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization stability and cytotoxicity. Eur J Pharm Biopharm. 74: 2010; 193-201.
- Lala R, Thorat A, Gargote C. Current trends in β- cyclodextrin based drug delivery systems. Int J Res Ayur Pharm. 2(5): 2011; 1520- 1526.
- Emanuele A D, Dinarvand R. Preparation, Characterization and Drug Release from Thermo responsive Microspheres. Int J Pharm. 1995; 237-242.
- K. Patel, R.J. Oswal. Nanosponge and Microsponges: A Novel Drug Delivery System. IJRPC. 2(2): 2012; 237-244.
- Trotta F, Dianzani C, Caldera F, Mognetti B, Cavalli R. The application of nanosponges to cancer drug delivery. Expert Opinion Drug Delivery 2014;11:931-41.
- Naga SJ, Nissankararao S, Bhimavarapu R, Sravanthi S, Vinusha K. Nanosponges: a versatile drug delivery system. Int J Pharm Life Sci 2013;4:2920-5.
- Güngör S, Erdal MS, Aksu B. New formulation strategies in topical antifungal therapy. J Cosmet Dermatol Sci Appl 2013;3:56.
- Trotta F. Cyclodextrin nanosponges and their applications. Cyclodextrins in pharmaceutics, cosmetics, and biomedicine. Current and Future Industrial Applications 2011. p. 323-42.
- Kaur G, Aggarwal G, Harikumar SL. Nanosponge: New colloidal drug delivery system for topical delivery. Indo Global J Pharm Sci 2015;5:53-7.
- Renu Kadian. Nanoparticles: a promising drug delivery approach. Asian J Pharm Clin Res 2018; 11:30-5.
- Che-Ming J Hu, Ronnie H Fang, Jonathan Copp, Brian T Luk, Liangfang Zhang. A biomimetic nanosponge that absorbs poreforming toxins. Nat Nanotechnol 2013;8:336–40.
- Swaminathan S, Vavia PR, Trotta F, Torne S. Formulation of betacyclodextrin based nanosponges of itraconazole. J InclPhenom Macrcycl Chem, 2007; 57(1-4): 89-94.
- Mateo C, Palomo JM, Fernandez-Lorente G, Guisan JM, Fernandez-Lorente R. Improvement of enzyme activity, stability and selectivity via immobilization techniques. Enzyme Microb Technol, 2007; 40: 1451-1463.
- Boscolo B, Trotta F, Ghibaudi E. High catalytic performances of Pseudomonas fluorescens lipase adsorbed on a new type of cyclodextrin-based nanosponges. J Mol Catal B Enzym, 2010; 62: 155-161.
- Cavalli R, Akhter AK, Bisazza A, Giustetto P, Trotta F, Vavia P. Nanosponge formulations as oxygen delivery systems. Int J Pharm, 2010; 402: 254-257.
- Sapino S, Carlotti ME, Cavalli R, Ugazio E, Berlier G, Gastaldi L, et al. Photochemical and antioxidant properties of gammaoryzanol in beta-cyclodextrin-based nanosponges. J Incl Phenom Macrocycl Chem, 2013; 75: 69-76