The Results of Vaccination and Reversed After Vaccination of Coronavirus Infection in Fergana Region for 2021–2022

: In this study, an analysis of the incidence of COVID–19 in the Fergana region was carried out, the number of vaccinated vaccination coverage and those who recovered after vaccination with COVID–19 was determined. The incidence was studied for the period from March 2020 to 2022. Since vaccination began in 2021, we analyzed those vaccinated and recovered from 2021 to 2022. The dynamics of the incidence of COVID–19 in the Fergana region was undulating. During the surveyed period, the intensive indicator of the incidence of COVID–19 was as follows: in the city of Fergana (887.6), Kuvasay–1169.5, Kuva–995, Sokh–737.2, Yazyavan–781, Altiarik–610.1, Fergana–472 cases per 100,000 populations. During this period, more than 7 million doses of COVID–19 vaccines were administered, and no side effects of the vaccines used were observed among those vaccinated.


INTRODUCTION
According to the World Health Organization (WHO), equitable access to safe and effective vaccines is essential to ending the COVID-19 pandemic, and it is encouraging to see so many vaccines making it through the trial and development stages [2,6,17,18].Environmental change, climate warming, increase in population density, development biotechnology and other factors provoke the emergence, and ever-increasing migration flows and the processes of globalization of the economy contributes the spread of new infections [7,9,11].Biological threats associated with epidemics of infectious diseases are global in nature [1,3,16].On February 11, 2020, the World Health Organization assigned the official name of the infection caused by the new coronavirus-COVID-19 ("Coronavirus disease 2019").On February 11, 2020, the International Committee on Taxonomy of Viruses assigned its own name to the causative agent of COVID-19 infection-SARS-CoV-2 [4,8,15,18].WHO works tirelessly with partners to develop, manufacture and introduce safe and effective vaccines [5,9,18].The coronavirus pandemic has highlighted a number of public health problems.Most of the world states were not ready to face this infection.The article is devoted to the problems of vaccination (COVID-19) in the Russian Federation.Scientific work is based on the interdisciplinary integration of medical, psychological, legal and sociological knowledge [10,13].WHO provided daily support to the Government of Uzbekistan through the provision of all technical guidance and advice during technical meetings, joint analysis of actions taken and recommendations for further emergency actions aimed at ensuring public health security [12,19].The WHO notes that the benefits of administering the COVID-19 vaccine outweigh the possible risks.For this reason, the experts of the Organization urge to be vaccinated against coronavirus infection and to introduce additional, booster doses in accordance with the recommendations [14,19].

THE AIM OF THE STUDY
The aim of this research was to study the evaluation of the results of vaccination and those who recovered after vaccination against coronavirus infection in the Fergana region.

THE OBJECT AND METHOD
Materials of vaccination and those who recovered after vaccination, a retrospective epidemiological analysis of data on the incidence of COVID-19 was carried out.The epidemiological method of the study was a retrospective analysis of the intensive indicator for

RESULTS AND DISCUSSIONS
The dynamics of the incidence of coronavirus infection is undulating.Distribution of registered patients with coronavirus infection by region according to gender: from March to December 2020, the total number of men is 435 patients, women 347 patients.In 2022, 5971 patients were registered men, 3988 women patients, in 2022, men were 1863 patients, women 1487 patients (Table 3).Since April 2021, vaccination of the Fergana region has begun, a vaccination program against coronavirus infection has been launched.
2,309,210 persons received primary vaccination with coronavirus vaccine during the specified period and the coverage rate as a percentage for primary vaccination was 95.3%.
Over 7 million doses of COVID-19 vaccines have been administered between April 2021 and 2022.Booster doses of COVID-19 vaccines are currently being used to prevent coronavirus infection.
Since the beginning of vaccination, several types of vaccines have been used: Astra-Zeneca, ZF-UZ Vac-2001, Sputnik V, Sputnik Light, Moderna, Pfizer, Sinovac (Table 4).Successful after vaccination with coronavirus infection in 2021-2022 year are presented in Table 5.

CONCLUSION
Thus, in the Fergana region, vaccination against coronavirus infection contributed to a sharp decrease in the incidence and no complications were recorded after the introduction of the coronavirus vaccine.In order to acquire public immunity, the use of vaccines has reduced the number of sick people and contributed to a decrease in the number of sick people, as well as preventing a pandemic and the inability of the population to work.The effectiveness of vaccination showed that in the vaccinated, the formation of collective immunity was achieved and the incidence of coronavirus infection decreased, also due to vaccination, those who recovered after vaccination amounted to only 0.1% of the total vaccinated.

COVID- 19 .
Statistical processing of the obtained data was carried out on the basis of special programs in Microsoft Excel.The diagnosis of COVID-19 was established on the basis of a polymerase chain reaction of a smear obtained from the nasopharyngeal region of a patient.

Table 1
From March to December 2020, 782 patients with COVID-19 were registered in the Fergana region.From January to December 2021, 9959 patients with COVID-19 were registered.From January to December 2022, 3350 patients with COVID-19 were registered.The registration of coronavirus infection patients was carried out based on the results of PCR diagnostics.The largest number of patients (absolute indicators) in the Fergana region for the specified period of time was registered in the city of Fergana city-2936, Kuvasay-1134, Fergana district-1150, Kuva-995, Altiarik-1318 (

Table 2 .
The number of registered patients with COVID-19 in Fergana region from March 2020 to 2022 (int.indicator) ISSN:

Table 3 .
The separation of registered patients with COVID-19 in Fergana region into men and women from 2020 to 2022 year ISSN:

Table 4 .
The ratio of the number of patients with COVID-19 to the number of vaccinated ISSN:

Table 5 .
The successful after vaccination with coronavirus infection in 2021-2022