A brief review on Triazole and its Pharmacological Application

: The triazole core is one of the most imperative and well known heterocycles which is composed of nitrogen atom which forms natural products with medicinal claims. Triazole moiety is present as a principal structural component in the drug categories such as antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepressant, antioxidant, antihistaminic, antitubercular, antidiabetic etc. The broad and potent activity of triazole and their derivatives has established them as pharmacologically significant platforms. The elementary heterocyclic rings present in the numerous medicinal mediators are 1,2,3-triazole and 1,2,4-triazole. A huge capacity of investigations has been approved on triazole and their results, which has proved the pharmacological status of this heterocyclic core. The current paper is an try to review the pharmacological activities reported for triazole derivatives in the current literature with an apprise of current research discoveries on this nuclei.


INTRODUCTION
Triazole is acknowledged as pyrrodiazole is single class of organic heterocyclic complexes containing a five-membered Di unsaturated ring assembly composed of three N atoms and two C atoms at non-adjacent positions.The modest form of the triazole domestic is triazole itself.Triazole is a white to pale yellow crystalline solid with a weak, distinctive odour, it is resolvable in water and alcohols.It melts at 120°C and boils at 260°C.It occurs as a pair of isomeric chemical composites as 1,2,3-triazole and 1,2,4triazole with molecular formula C2 H3 N3, and a molecular weight of 69.06 [1].There are two isomers are, [1,2,4]Triazole Kesavan Karthikeyan et al [2] reported the synthesized compound shows potent anti-fungal activity against the Candida albicans and Aspergillus niger pathogen.
Xuezhen Zhu et al [3] the group of scientist work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective Breast Cancer Resistance Protein (BCRP) inhibitors.

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Zhe Zhang et al [5] present work describes synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents.A series of novel pleuromutilin derivatives possessing 1,2,3-triazole moieties were synthesized via click reactions under mild conditions.The in vitro antibacterial activities of these derivatives against 4 strains of S. aureus (MRSA ATCC 43300, ATCC 29213, AD 3, and 144) and 1 strain of E. coli (ATCC 25922) were tested by the broth dilution method.Kesavan Karthikeyan et al [9] the group of co-workers Synthesize the1,2,3-triazole tethered 3-hydroxy-2-oxindoles: which is used as corrosion inhibitors for steel in acidic medium and their compound shows potent anti-microbial activity.[18] have synthesized a potent combretastatin A-4 analogs containing 1,2,4-triazole which carried out antiproliferative, anti-tubulin activity, and docking study.
Ana I Matesanz et al [19] New Pt (II) have developed the triazole thiosemicarbazone' complexes.And analyse their reactivity and potential antitumoral activity.
Guo-qing Lu et al [20]] reported the Design, synthesis and biological evaluation of novel uracil derivative bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Zhao et al[4] current work describes anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties

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et al[6] existing work describes synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors.Current investigation of anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay.All new compounds underwent justification for their target structures via microanalytical and spectral data.SAR studies were performed and molecular docking done to check the activity.Awasthi et al[7] present work describes Insights into the interaction of potent antimicrobial chalcone triazole analogues with human serum albumin.Nguyen D. Thanh et al[8] present work describes Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4-H chromene D-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activitie

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et al[10] reported the Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer.They design and synthesis, 18F-radiolabeling & galectin-1 inhibition studies.et al[11] reported the Synthesis of 1H-pyrrolo[2,3-d]  pyrimidine-1,2,3-triazole derivatives.Which studies the potent anti-tubercular agents.Rastegari et al[12] have reported to design and synthesis of novel 1,2,3 triazole chromenone carboxamide derivatives which shows potent anti-Alzheimer's activity.Ramprasad et al[13] have developed the novel Synthesis of quinoline-triazole analogs for antitubercular properties via molecular hybridization approach.Mousa et al[14] a group of scientists developed Triazole modified tetraiodothyro acetic acid conjugated to Polyethylene Glycol.Which shows high affinity thyrointegrin αv β3 Antagonist with Potent Anticancer Activities in Glioblastoma Multiforme.Queiroz et al[15] have study the Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and the synthesized compound shows cytotoxic activity.et al[16] have Synthesize schiff bases tethered 1,2,4-triazole and pyrazole rings and spectroscopic characterization, to study DFT calculations, molecular dynamics simulations and biological evaluation compound.Najafi et al[17] they developed the novel tacrine-coumarin hybrids linked 1,2,3-triazole compounds which shows as anti-Alzheimer's activity.In vitro and in vivo biological evaluation of compound and also study docking.